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Crucial role of the orexin-B C-terminus in the induction of OX 1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis

Résumé : Orexins (A and B) are hypothalamic peptides that interact with OX1 and OX2 receptors and are involved in the sleep/wake cycle. We previously demonstrated that OX1 receptors are highly expressed in colon cancer tumours and colonic cancer cell lines where orexins induce apoptosis and inhibit tumour growth in preclinical animal models. The present study explored the structure-function relationships of orexin-B and OX1 receptors.
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https://hal.archives-ouvertes.fr/hal-01432232
Contributor : Ludivine Houel <>
Submitted on : Wednesday, January 11, 2017 - 4:23:18 PM
Last modification on : Friday, September 11, 2020 - 3:17:56 AM

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Pascal Nicole, Pierre Couvineau, Nadege Jamin, Thierry Voisin, Alain Couvineau. Crucial role of the orexin-B C-terminus in the induction of OX 1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis. British Journal of Pharmacology, Wiley, 2015, 172 (21), pp.5211 - 5223. ⟨10.1111/bph.13287⟩. ⟨hal-01432232⟩

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