WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

Lauren E. Walker , Damir Janigro , Uwe Heinemann , Raili Riikonen , Christophe Bernard (1) , Manisha Patel

1 INS - Institut de Neurosciences des Systèmes

Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candidates are in development. In this review, we discuss the major areas of focus including inflammation, blood-brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors.

Domaines: Neurosciences

Lauren E. Walker, Damir Janigro, Uwe Heinemann, Raili Riikonen, Christophe Bernard, et al.. WONOEP appraisal: Molecular and cellular biomarkers for epilepsy. Epilepsia, 2016, 57 (9), pp.1354-1362. ⟨10.1111/epi.13460⟩. ⟨hal-01431291⟩