Skip to Main content Skip to Navigation
Journal articles

Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges

Abstract : Interpretation of hemodynamic responses in epilepsy is hampered by an incomplete understanding of the underlying neurovascular coupling, especially the contributions of excitation and inhibition. We made simultaneous multimodal recordings of local field potentials (LFPs), firing of individual neurons, blood flow, and oxygen level in the somatosensory cortex of anesthetized rats. Epileptiform discharges induced by bicuculline injections were used to trigger large local events. LFP and blood flow were robustly coupled, as were LFP and tissue oxygen. In a parametric linear model, LFP and the baseline activities of cerebral blood flow and tissue partial oxygen tension contributed significantly to blood flow and oxygen responses. In an analysis of recordings from 402 neurons, blood flow/tissue oxygen correlated with the discharge of putative interneurons but not of principal cells. Our results show that interneuron activity is important in the vascular and metabolic responses during epileptiform discharges.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-01431280
Contributor : Viktor Jirsa Connect in order to contact the contributor
Submitted on : Tuesday, January 10, 2017 - 4:32:59 PM
Last modification on : Tuesday, October 19, 2021 - 6:48:46 PM

Links full text

Identifiers

Citation

Sandrine Saillet, Pascale P. Quilichini, Antoine Ghestem, Bernard Giusiano, Anton I. Ivanov, et al.. Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges. Journal of Neurophysiology, American Physiological Society, 2016, 115 (3), pp.1157-1169. ⟨10.1152/jn.00994.2014⟩. ⟨hal-01431280⟩

Share

Metrics

Record views

552