Astrocytes gate Hebbian synaptic plasticity in the striatum

Abstract : Astrocytes, via excitatory amino-acid transporter type-2 (EAAT2), are the major sink for released glutamate and contribute to set the strength and timing of synaptic inputs. The conditions required for the emergence of Hebbian plasticity from distributed neural activity remain elusive. Here, we investigate the role of EAAT2 in the expression of a major physiologically relevant form of Hebbian learning, spike timing-dependent plasticity (STDP). We find that a transient blockade of EAAT2 disrupts the temporal contingency required for Hebbian synaptic plasticity. Indeed, STDP is replaced by aberrant non-timing-dependent plasticity occurring for uncorrelated events. Conversely, EAAT2 overexpression impairs the detection of correlated activity and precludes STDP expression. Our findings demonstrate that EAAT2 sets the appropriate glutamate dynamics for the optimal temporal contingency between pre-and postsynaptic activity required for STDP emergence, and highlight the role of astrocytes as gatekeepers for Hebbian synaptic plasticity.
Type de document :
Article dans une revue
Nature Communications, Nature Publishing Group, 2016, 7, pp.13845. 〈10.1038/ncomms13845〉
Liste complète des métadonnées

http://hal.upmc.fr/hal-01429821
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : lundi 9 janvier 2017 - 11:05:31
Dernière modification le : mardi 10 janvier 2017 - 09:44:22
Document(s) archivé(s) le : lundi 10 avril 2017 - 13:29:38

Fichier

ncomms13845.pdf
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

UPMC | PSL

Citation

Silvana Valtcheva, Laurent Venance. Astrocytes gate Hebbian synaptic plasticity in the striatum. Nature Communications, Nature Publishing Group, 2016, 7, pp.13845. 〈10.1038/ncomms13845〉. 〈hal-01429821〉

Partager

Métriques

Consultations de
la notice

67

Téléchargements du document

22