Organic Electron Donors as Powerful Single-Electron Transfer Reducing Agents in Organic Synthesis

Julie Broggi (1) , Thierry Terme (1) , Patrice Vanelle (1)

1 ICR - Institut de Chimie Radicalaire

One-electron reduction is commonly used in organic chemistry to achieve radical formation via the stepwise transfer of one or two electrons from a donor to an organic substrate. Beyond metallic reagents, Single-Electron Transfer reducers based on neutral organic molecules have emerged as an attractive novel source of reducing electrons. The past twenty years have thus seen the blossom of a particular class of organic reducing agents, the electron-rich olefins, and the multiplication of their applications in organic synthesis. These powerful neutral ground-state organic electron donors have since showed several significant advantages in the reduction of numerous organic substrates. This review gives an overview of the different types of organic donors and of their specific characteristics in organic transformations.

Mots clés: Organic Electron Donors; Reduction; Electron-rich Olefins; Electron Transfer

Domaines: Chimie organique

Julie Broggi, Thierry Terme, Patrice Vanelle. Organic Electron Donors as Powerful Single-Electron Transfer Reducing Agents in Organic Synthesis. Angewandte Chemie International Edition, 2014, 53 (2), pp.384-413. ⟨10.1002/anie.201209060⟩. ⟨hal-01428063⟩