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Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

Abstract : The transmembrane domains ( TMD) in membrane receptors play a key role in cell signaling. As previously shown by us a peptide targeting the TMD of neuropilin-1 ( MTP-NRP1), blocks cell proliferation, cell migration and angiogenesis in vitro, and decreases glioblastoma growth in vivo. We now explored the clinical potential of MTP-NRP1 on breast cancer models and demonstrate that MTP-NRP1 blocks proliferation of several breast cancer lines including the MDA-MB-231, a triple negative human breast cancer cell line. In models with long term in vivo administration of the peptide, MTP-NRP1 not only reduced tumor volume but also decreased number and size of breast cancer metastases. Strikingly, treating mice before tumors developed protected from metastasis establishment/formation. Overall, our results report that targeting the TMD of NRP1 in breast cancer is a potent new strategy to fight against breast cancer and related metastasis.
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https://hal.archives-ouvertes.fr/hal-01412954
Contributor : Brigitte Gaillard Connect in order to contact the contributor
Submitted on : Friday, December 9, 2016 - 10:24:48 AM
Last modification on : Thursday, November 5, 2020 - 3:58:27 PM

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Alexia Arpel, Coralie Gamper, Caroline Spenlé, Aurore Fernandez, Laurent Jacob, et al.. Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide. Oncotarget, Impact journals, 2016, 7 (34), ⟨10.18632/oncotarget.10101⟩. ⟨hal-01412954⟩

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