Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T 1 -MRI

Abstract : We report first prototypes of responsive lanthanide(III) complexes that can be monitored independently in three complementary imaging modalities. Through the appropriate choice of lanthanide(III) cations, the same reactive ligand can be used to form complexes providing detection by (i) visible (Tb3+) and near-infrared (Yb3+) luminescence, (ii) PARACEST- (Tb3+, Yb3+), or (iii) T1-weighted (Gd3+) MRI. The use of lanthanide(III) ions of different natures for these imaging modalities induces only a minor change in the structure of complexes that are therefore expected to have a single biodistribution and cytotoxicity.
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https://hal.archives-ouvertes.fr/hal-01407004
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Submitted on : Thursday, December 1, 2016 - 5:11:46 PM
Last modification on : Friday, August 16, 2019 - 3:58:04 PM

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Jiefang He, Célia S. Bonnet, Svetlana V. Eliseeva, Sara Lacerda, Thomas Chauvin, et al.. Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T 1 -MRI. Journal of the American Chemical Society, American Chemical Society, 2016, 138 (9), pp.2913 - 2916. ⟨10.1021/jacs.5b12084⟩. ⟨hal-01407004⟩

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