Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms, Physiological Reviews, vol.92, issue.3, pp.1235-1316, 2012. ,
DOI : 10.1152/physrev.00037.2010
URL : http://physrev.physiology.org/content/physrev/92/3/1235.full.pdf
Insights into the mechanism by which kisspeptin stimulates a preovulatory LH surge and ovulation in seasonally acyclic ewes: Potential role of estradiol, Domestic Animal Endocrinology, vol.38, issue.4, pp.289-298, 2010. ,
DOI : 10.1016/j.domaniend.2010.01.001
URL : https://hal.archives-ouvertes.fr/hal-01129443
Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications, Neuroendocrinology, vol.97, issue.2, pp.193-202, 2013. ,
DOI : 10.1159/000336376
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902960
Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.11, pp.4315-4323, 2009. ,
DOI : 10.1210/jc.2009-0406
Twice-Weekly Administration of Kisspeptin-54 for 8 Weeks Stimulates Release of Reproductive Hormones in Women With Hypothalamic Amenorrhea, Clinical Pharmacology & Therapeutics, vol.20, issue.6, pp.840-847, 2010. ,
DOI : 10.1210/en.2005-1397
) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges, Endocrinology, vol.147, issue.2, pp.1007-1013, 2006. ,
DOI : 10.1210/en.2005-1261
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54, The Journal of Physiology, vol.15, issue.2, pp.379-386, 2004. ,
DOI : 10.1046/j.1365-2826.2003.00871.x
A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10, AJP: Endocrinology and Metabolism, vol.298, issue.2, pp.296-303, 2010. ,
DOI : 10.1152/ajpendo.00426.2009
Chronic Administration of the Metastin/Kisspeptin Analog KISS1-305 or the Investigational Agent TAK-448 Suppresses Hypothalamic Pituitary Gonadal Function and Depletes Plasma Testosterone in Adult Male Rats, Endocrinology, vol.153, issue.11, pp.5297-5308, 2012. ,
DOI : 10.1210/en.2012-1388
Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-683, an investigational metastin analogue in healthy men, British Journal of Clinical Pharmacology, vol.29, issue.Suppl. 1, pp.381-391, 2013. ,
DOI : 10.1200/JCO.2010.32.8815
Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins, Journal of Medicinal Chemistry, vol.58, issue.8, pp.3459-3470, 2015. ,
DOI : 10.1021/jm5019675
URL : https://hal.archives-ouvertes.fr/hal-01170460
Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration, Journal of Medicinal Chemistry, vol.43, issue.9, pp.1664-1669, 2000. ,
DOI : 10.1021/jm9909645
Long-Acting Lipidated Analogue of Human Pancreatic Polypeptide Is Slowly Released into Circulation, Journal of Medicinal Chemistry, vol.54, issue.8, pp.2658-2667, 2011. ,
DOI : 10.1021/jm101357e
Trypsin resistance of a decapeptide KISS1R agonist containing an N??-methylarginine substitution, Bioorganic & Medicinal Chemistry Letters, vol.22, issue.20, pp.6328-6332, 2012. ,
DOI : 10.1016/j.bmcl.2012.08.087
Sustained Exposure to the Investigational Kisspeptin Analog, TAK-448, Down-Regulates Testosterone into the Castration Range in Healthy Males and in Patients With Prostate Cancer: Results From Two Phase 1 Studies, The Journal of Clinical Endocrinology & Metabolism, vol.99, issue.8, pp.99-1445, 2014. ,
DOI : 10.1210/jc.2013-4236
Seasonality of Reproduction in Mammals: Intimate Regulatory Mechanisms and Practical Implications, Reproduction in Domestic Animals, vol.24, issue.2, pp.40-47, 2008. ,
DOI : 10.1152/ajpregu.00299.2001
Differential changes in luteinizing hormone secretion after administration of the investigational metastin/kisspeptin analog TAK-683 in goats, Animal Reproduction Science, vol.159, pp.87-93, 2015. ,
DOI : 10.1016/j.anireprosci.2015.05.016
Ovarian and Hormonal Responses to Follicular Phase Administration of Investigational Metastin/Kisspeptin Analog, TAK-683, in Goats, Reproduction in Domestic Animals, vol.70, issue.2, pp.338-342, 2014. ,
DOI : 10.1016/j.jpba.2012.05.033
= 4; Exp. 2), PeerJ, vol.131, issue.1, p.1382, 2015. ,
DOI : 10.7717/peerj.1382/supp-1
Humoral Immune Response to Equine Chorionic Gonadotropin in Ewes: Association with Major Histocompatibility Complex and Interference with Subsequent Fertility1, Biology of Reproduction, vol.61, issue.1, pp.209-218, 1999. ,
DOI : 10.1095/biolreprod61.1.209
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty, Journal of Neuroscience, vol.25, issue.49, pp.11349-11356, 2005. ,
DOI : 10.1523/JNEUROSCI.3328-05.2005
Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat, Biochemical and Biophysical Research Communications, vol.320, issue.2, pp.383-388, 2004. ,
DOI : 10.1016/j.bbrc.2004.05.185
Developmental Changes in Hypothalamic Kiss1 Expression during Activation of the Pulsatile Release of Luteinising Hormone in Maturing Ewe Lambs, Journal of Neuroendocrinology, vol.4, issue.9, pp.815-822, 2011. ,
DOI : 10.1371/journal.pone.0008334
Kisspeptin activates the hypothalamic-adenohypophyseal-gonadal axis in prepubertal ewe lambs, Reproduction, vol.141, issue.4, pp.541-548, 2011. ,
DOI : 10.1530/REP-10-0467
URL : https://hal.archives-ouvertes.fr/hal-01129489
Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts, Reproduction, vol.135, issue.6, pp.879-887, 2008. ,
DOI : 10.1530/REP-07-0502
Recent advances in the understanding and management of delayed puberty, Archives of Disease in Childhood, vol.170, issue.(Suppl 1), pp.10-1136, 2015. ,
DOI : 10.1530/EJE-13-0894
Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors, Neuropharmacology, vol.75, pp.164-171, 2013. ,
DOI : 10.1016/j.neuropharm.2013.07.012
URL : https://hal.archives-ouvertes.fr/hal-00860085
Kisspeptin Regulation of Arcuate Neuron Excitability in Kisspeptin Receptor Knockout Mice, Endocrinology, vol.156, issue.5, pp.1815-1827, 2015. ,
DOI : 10.1210/en.2014-1845
Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands, ACS Medicinal Chemistry Letters, vol.2, issue.1, pp.53-57, 2011. ,
DOI : 10.1021/ml1002053
Human kisspeptins activate neuropeptide FF2 receptor, Neuroscience, vol.170, issue.1, pp.117-122, 2010. ,
DOI : 10.1016/j.neuroscience.2010.06.058
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat, Neuroendocrinology, vol.80, issue.4, pp.264-272, 2004. ,
DOI : 10.1159/000083140
Delivery of Therapeutic Peptides and Proteins to the CNS, Adv. Pharmacol, vol.71, pp.277-299, 2014. ,
DOI : 10.1016/bs.apha.2014.06.004
Multitasking in Gonadotropin-Releasing Hormone Neuron Dendrites, Neuroendocrinology, vol.102, issue.1-2, pp.1-7, 2015. ,
DOI : 10.1159/000368364
GnRH Neurons Elaborate a Long-Range Projection with Shared Axonal and Dendritic Functions, Journal of Neuroscience, vol.33, issue.31, pp.12689-12697, 2013. ,
DOI : 10.1523/JNEUROSCI.0579-13.2013
URL : http://www.jneurosci.org/content/jneuro/33/31/12689.full.pdf
Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals, Endocrinology, vol.149, issue.8, pp.3926-3932, 2008. ,
DOI : 10.1210/en.2007-1487
Pulsatile Secretion of Gonadotropin-Releasing Hormone by Rat Hypothalamic Explants of GnRH Neurons without Cell Bodies, Neuroendocrinology, vol.66, issue.5, pp.305-312, 1997. ,
DOI : 10.1159/000127253
Activation of Neurokinin 3 Receptors Stimulates GnRH Release in a Location-Dependent but Kisspeptin-Independent Manner in Adult Mice, Endocrinology, vol.154, issue.11, pp.3984-3989, 2013. ,
DOI : 10.1210/en.2013-1479
RF9 Excitation of GnRH Neurons Is Dependent Upon Kiss1r in the Adult Male and Female Mouse, Endocrinology, vol.155, issue.12, pp.4915-4924, 2014. ,
DOI : 10.1210/en.2014-1517
GABA-and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice, J. Neurosci, vol.19, issue.6, pp.2037-2050, 1999. ,
The GPR54 Gene as a Regulator of Puberty, Obstetrical & Gynecological Survey, vol.59, issue.5, pp.1614-1627, 2003. ,
DOI : 10.1097/00006254-200405000-00020
Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice, Endocrinology, vol.154, issue.12, pp.4939-4945, 2013. ,
DOI : 10.1210/en.2013-1502
Changes in pulsatile LH secretion after ovariectomy in Ile-de-France ewes in two seasons, Reproduction, vol.73, issue.1, pp.173-183, 1985. ,
DOI : 10.1530/jrf.0.0730173
Radio-immunologic determination of plasma lutenizing hormone in sheep. Comparison with the biologic determination of LH by the diminution of ovarian ascorbic acid, and example of the application to measure of the blood LH in ewes, C. R. Seances Acad. Sci. D, vol.266, issue.25, pp.2352-2354, 1968. ,