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The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors

Abstract : We recently developed the synthesis of ultrasmall gadolinium-based nanoparticles (GBN), (hydrodynamic diameter <5 nm) characterized by a safe behavior after intravenous injection (renal clearance, preferential accumulation in tumors). Owing to the presence of gadolinium ions, GBN can be used as contrast agents for magnetic resonance imaging (MRI) and as radiosensitizers. The attempt to determine the most opportune delay between the intravenous injection of GBN and the irradiation showed that a very low content of radiosensitizing nanoparticles in the tumor area is sufficient (0.1 μg/g of particles, i.e. 15 ppb of gadolinium) for an important increase of the therapeutic effect of irradiation. Such a promising and unexpected result is assigned to a suited distribution of GBN within the tumor, as revealed by the X-ray fluorescence (XRF) maps.
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https://hal.archives-ouvertes.fr/hal-01405772
Contributor : Béatrice Rayet <>
Submitted on : Wednesday, November 30, 2016 - 2:01:13 PM
Last modification on : Wednesday, November 4, 2020 - 2:58:54 PM

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Sandrine Dufort, Géraldine Le Duc, Murielle Salomé, Valerie Bentivegna, Lucie Sancey, et al.. The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors. Scientific Reports, Nature Publishing Group, 2016, 6, pp.29678. ⟨10.1038/srep29678⟩. ⟨hal-01405772⟩

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