F. Costa, J. Hagan, J. Calcagno, M. Kane, P. Torgerson et al., Global Morbidity and Mortality of Leptospirosis: A Systematic Review, PLOS Neglected Tropical Diseases, vol.9, issue.9, p.26379143
DOI : 10.1371/journal.pntd.0003898.s016

A. Ko, C. Goarant, and M. Picardeau, Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen, Nature Reviews Microbiology, vol.27, issue.10, pp.736-783, 2009.
DOI : 10.1038/nrmicro2208

URL : https://hal.archives-ouvertes.fr/pasteur-00450871

R. Schrier and A. Arf, ARF, AKI, or ATN?, Nature Reviews Nephrology, vol.296, issue.3, p.125, 2010.
DOI : 10.1038/nrneph.2010.1

C. Haas, W. Lehne, P. Muck, A. Boehm, J. Rupp et al., Acute kidney injury and thrombocytopenic fever???consider the infrequent causes, The American Journal of Emergency Medicine, vol.31, issue.2, pp.441-446, 2013.
DOI : 10.1016/j.ajem.2012.04.007

E. Daher, R. Lima, S. Junior, G. Silva, E. Karbage et al., Clinical presentation of leptospirosis: a retrospective study of 201 patients in a metropolitan city of Brazil, Braz J Infect Dis, vol.1430, issue.1, pp.3-10, 2010.

V. Sitprija, V. Pipatanagul, K. Mertowidjojo, V. Boonpucknavig, and S. Boonpucknavig, Pathogenesis of renal disease in leptospirosis: Clinical and experimental studies, Kidney International, vol.17, issue.6, pp.827-863, 1980.
DOI : 10.1038/ki.1980.95

R. Ghasemian, M. Shokri, A. Makhlough, and M. Suraki-azad, The course and outcome of renal failure due to human leptospirosis referred to a hospital in North of Iran; A follow-up study. Caspian journal of internal medicine, Epub PMID, vol.710, issue.1, pp.7-12, 2016.

N. Herath, S. Kularatne, K. Weerakoon, A. Wazil, N. Subasinghe et al., Long term outcome of acute kidney injury due to leptospirosis? A longitudinal study in Sri Lanka, BMC Research Notes, vol.7, issue.1, pp.398-4080986, 2014.
DOI : 10.1186/1756-0500-7-398

E. Atasoyu, V. Turhan, S. Unver, T. Evrenkaya, and S. Yildirim, A case of leptospirosis presenting with end-stage renal failure, Nephrology Dialysis Transplantation, vol.20, issue.10, pp.2290-2292, 2005.
DOI : 10.1093/ndt/gfi014

D. Ashford, R. Kaiser, R. Spiegel, B. Perkins, R. Weyant et al., Asymptomatic infection and risk factors for leptospirosis in Nicaragua. The American journal of tropical medicine and hygiene, pp.5-6249, 2000.

P. Bovet, C. Yersin, F. Merien, C. Davis, and P. Perolat, Factors associated with clinical leptospirosis: a population-based case- control study in the Seychelles (Indian Ocean), International Journal of Epidemiology, vol.28, issue.3, pp.583-90, 1999.
DOI : 10.1093/ije/28.3.583

E. Chow, J. Deville, J. Nally, M. Lovett, and K. Nielsen-saines, Prolonged leptospira urinary shedding in a 10- year-old girl. Case reports in pediatrics, pp.169013-22606527, 2012.

A. Bal, C. Gravekamp, R. Hartskeerl, D. Meza-brewster, J. Korver et al., Detection of leptospires in urine by PCR for early diagnosis of leptospirosis, J Clin Microbiol. Epub PMID, vol.32, issue.8, pp.1894-1902, 1994.

C. Ganoza, M. Matthias, M. Saito, M. Cespedes, E. Gotuzzo et al., Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira, PLoS Neglected Tropical Diseases, vol.171, issue.2, p.20186328, 2010.
DOI : 10.1371/journal.pntd.0000612.s003

H. Yang, C. Hung, S. Liu, Y. Guo, Y. Chen et al., Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence, PLOS Neglected Tropical Diseases, vol.17, issue.Suppl 9, pp.4105-4599860, 2015.
DOI : 10.1371/journal.pntd.0004105.s002

R. Correa-rotter, C. Wesseling, and R. Johnson, CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy American journal of kidney diseases: the official journal of the National Kidney Foundation, pp.506-526, 2014.

K. Murray, R. Fischer, D. Chavarria, C. Duttmann, M. Garcia et al., Mesoamerican nephropathy: a neglected tropical disease with an infectious etiology? Microbes and infection, Institut Pasteur, vol.17, issue.10, pp.671-676, 2015.

V. Jha and N. Prasad, CKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities American journal of kidney diseases: the official journal of the National Kidney Foundation, 2016.

D. Tripathy and L. Hanson, SOME OBSERVATIONS ON CHRONIC LEPTOSPIRAL CARRIER STATE IN GERBILS EXPERIMENTALLY INFECTED WITH Leptospira grippotyphosa, Journal of Wildlife Diseases, vol.12, issue.1, pp.55-63, 1976.
DOI : 10.7589/0090-3558-12.1.55

N. Miller, Observations of the carrier state in hamsters infected with Leptospira interrogans serotype pomona, Medical Microbiology and Immunology, vol.47, issue.1, pp.1-8, 1972.
DOI : 10.1007/BF02122002

R. Zuerner, D. Alt, and M. Palmer, Serovar Hardjo, Veterinary Pathology, vol.12, issue.1, pp.403-414, 2012.
DOI : 10.1016/S0378-1135(99)00103-0

M. Matsui, L. Roche, M. Soupe-gilbert, M. Roudier, V. Moniquet et al., Experimental Hamster Infection with a Strain of Leptospira borgpetersenii Ballum Isolated from a Reservoir Mouse in New Caledonia . The American journal of tropical medicine and hygiene, pp.982-987, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01163059

A. Bharti, J. Nally, J. Ricaldi, M. Matthias, M. Diaz et al., Leptospirosis: a zoonotic disease of global importance, The Lancet Infectious Diseases, vol.3, issue.12, pp.757-71, 2003.
DOI : 10.1016/S1473-3099(03)00830-2

A. Monahan, J. Callanan, and J. Nally, Host-pathogen interactions in the kidney during chronic leptospirosis. Veterinary pathology, pp.792-801, 2009.

A. Monahan, J. Callanan, and J. Nally, Proteomic Analysis of Leptospira interrogans Shed in Urine of Chronically Infected Hosts, Infection and Immunity, vol.76, issue.11, pp.4952-4960, 2008.
DOI : 10.1128/IAI.00511-08

J. Millan, M. Candela, J. Lopez-bao, M. Pereira, M. Jimenez et al., Leptospirosis in Wild and Domestic Carnivores in Natural Areas in Andalusia, Spain. Vector borne and zoonotic diseases, Larchmont, NY, vol.9, issue.5, pp.549-54, 2008.

M. Tucunduva-de-faria, D. Athanazio, G. Ramos, E. Silva, E. Reis et al., Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection, Journal of Comparative Pathology, vol.137, issue.4, pp.231-239, 2007.
DOI : 10.1016/j.jcpa.2007.08.001

C. Yang, M. Wu, M. Pan, J. Hong, C. Yu et al., Leptospira outer membrane protein activates NF-kB and downstream genes expressed in medullary thick ascending limb cells, J Am Soc Nephrol, vol.11, issue.11, pp.2017-2043, 2000.

C. Yang, M. Wu, M. Pan, W. Hsieh, A. Vandewalle et al., The Leptospira Outer Membrane Protein LipL32 Induces Tubulointerstitial Nephritis-Mediated Gene Expression in Mouse Proximal Tubule Cells, Journal of the American Society of Nephrology, vol.13, issue.8, pp.2037-2082, 2002.
DOI : 10.1097/01.ASN.0000022007.91733.62

D. Geller, C. Lowenstein, R. Shapiro, A. Nussler, D. Silvio et al., Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes., Proceedings of the National Academy of Sciences, vol.90, issue.8, pp.3491-3496, 1993.
DOI : 10.1073/pnas.90.8.3491

N. Hegarty, L. Young, C. Kirwan, O. Neill, A. Bouchier-hayes et al., Nitric oxide in unilateral ureteral obstruction: Effect on regional renal blood flow, Kidney International, vol.59, issue.3, pp.1059-65, 2001.
DOI : 10.1046/j.1523-1755.2001.00589.x

P. Subrahmanian, G. Abraham, K. Thirumurthi, M. Mathew, Y. Reddy et al., Reversible acute kidney injury due to bilateral papillary necrosis in a patient with leptospirosis and diabetes mellitus, Indian journal of nephrology, vol.22, issue.5, pp.392-396, 2012.

G. Pretre, N. Olivera, M. Cedola, S. Haase, L. Alberdi et al., Role of inducible nitric oxide synthase in the pathogenesis of experimental leptospirosis, Microbial Pathogenesis, vol.51, issue.3, pp.203-211, 2011.
DOI : 10.1016/j.micpath.2011.03.011

M. Fanton-d-'andon, N. Quellard, B. Fernandez, G. Ratet, S. Lacroix-lamande et al., Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways, PLoS Neglected Tropical Diseases, vol.4, issue.1, p.3907306, 2014.
DOI : 10.1371/journal.pntd.0002664.g006

URL : https://hal.archives-ouvertes.fr/pasteur-01415741

M. Trojanowska, Mediators of fibrosis. The open rheumatology journal, pp.70-71, 2012.

J. Perez, F. Brescia, J. Becam, C. Mauron, and C. Goarant, Rodent Abundance Dynamics and Leptospirosis Carriage in an Area of Hyper-Endemicity in New Caledonia, PLoS Neglected Tropical Diseases, vol.6, issue.10, 2011.
DOI : 10.1371/journal.pntd.0001361.s003

URL : https://hal.archives-ouvertes.fr/pasteur-00655437

S. Faine, B. Adler, C. Bolin, and P. Perolat, Leptospira and Leptospirosis, Melbourne , Australia: MedSci, 1999.

A. Farris and C. Alpers, What is the best way to measure renal fibrosis?: A pathologist's perspective. Kidney international supplements, pp.9-15, 2014.

K. Lourdault, L. Wang, A. Vieira, J. Matsunaga, R. Melo et al., Oral Immunization with Escherichia coli Expressing a Lipidated Form of LigA Protects Hamsters against Challenge with Leptospira interrogans Serovar Copenhageni, Infection and Immunity, vol.82, issue.2, pp.893-902, 2014.
DOI : 10.1128/IAI.01533-13

N. Wuscher and M. Huerre, Method of Warthin-Starry modified with pyrocatechol: interest for revealing spirochetes and infectious agents [Méthode de Warthin-Starry modifiée au pyrocatechol: intérêt pour la mise en évidence des spirochètes et agents infectieux]. Revue française d'histotechnologie, pp.5-8, 1993.

M. Matsui, V. Rouleau, L. Bruyère-ostells, and C. Goarant, Gene Expression Profiles of Immune Mediators and Histopathological Findings in Animal Models of Leptospirosis: Comparison between Susceptible Hamsters and Resistant Mice, Infection and Immunity, vol.79, issue.11, pp.4480-92, 2011.
DOI : 10.1128/IAI.05727-11

URL : https://hal.archives-ouvertes.fr/pasteur-00655436

F. Merien, D. Portnoi, P. Bourhy, F. Charavay, A. Berlioz-arthaud et al., species in human leptospirosis, FEMS Microbiology Letters, vol.249, issue.1, pp.139-186, 2005.
DOI : 10.1016/j.femsle.2005.06.011

R. Stoddard, J. Gee, P. Wilkins, K. Mccaustland, and A. Hoffmaster, Detection of pathogenic Leptospira spp. through TaqMan polymerase chain reaction targeting the LipL32 gene. Diagnostic microbiology and infectious disease, Epub, vol.64, issue.3, pp.247-55, 2009.

L. Richer, H. Potula, R. Melo, A. Vieira, and M. Gomes-solecki, Mouse Model for Sublethal Leptospira interrogans Infection, Infection and Immunity, vol.83, issue.12, pp.4693-700, 2015.
DOI : 10.1128/IAI.01115-15

S. Villanueva, M. Saito, Y. Tsutsumi, T. Segawa, R. Baterna et al., High virulence in hamsters of four dominant Leptospira serovars isolated from rats in the Philippines, Microbiology, vol.160, issue.Pt_2, pp.418-446, 2014.
DOI : 10.1099/mic.0.072439-0

C. Santos, J. Macedo, M. Bandeira, A. Chagas, . Jr et al., Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes, Journal of Medical Microbiology, vol.59, issue.9, pp.1101-1107, 2010.
DOI : 10.1099/jmm.0.021089-0

M. Ferrer, E. Scharrig, L. Alberdi, M. Cedola, G. Pretre et al., Decay-Accelerating Factor 1 Deficiency Exacerbates Leptospiral-Induced Murine Chronic Nephritis and Renal Fibrosis, PLoS ONE, vol.35, issue.7, pp.102860-4102560, 2014.
DOI : 10.1371/journal.pone.0102860.t001

URL : http://doi.org/10.1371/journal.pone.0102860

S. Azizi, E. Tajbakhsh, M. Hajimirzaei, G. Varnamkhast, M. Sadeghian et al., Evaluation of ???white-spotted kidneys??? associated with leptospirosis by polymerase chain reaction based <i>LipL32</i> gene in slaughtered cows, Journal of the South African Veterinary Association, vol.83, issue.1, pp.1-5, 2012.
DOI : 10.4102/jsava.v83i1.69

Z. Yener and H. Keles, Immunoperoxidase and histopathological examinations of leptospiral nephritis in cattle Journal of veterinary medicine A, Physiology, pathology, clinical medicine, Epub, vol.48, issue.710, pp.441-716, 2001.

P. Pierce, J. Utz, E. Lack, D. Connor, F. Chandler et al., Pathology of infectious diseases, 1997.

W. Shieh, C. Edwards, P. Levett, S. Zaki, and . Leptospirosis, Tropical Infectious Diseases: Principles, Pathogens and Practice (Third Edition) Tropical Infectious Diseases: Principles, Pathogens and Practice, pp.303-310, 2011.

V. Boonpucknavig, G. Douangchawee, and K. Niwattaykul, Infectious Diseases and Tropical Disease Pathology: SY16-2A PATHOLOGY OF LEPTOSPIROSIS: AUTOPSY STUDY, Pathology, vol.46, 2014.

M. Matsui, V. Rouleau, L. Bruyere-ostells, and C. Goarant, Gene Expression Profiles of Immune Mediators and Histopathological Findings in Animal Models of Leptospirosis: Comparison between Susceptible Hamsters and Resistant Mice, Infection and Immunity, vol.79, issue.11, pp.4480-92, 2011.
DOI : 10.1128/IAI.05727-11

URL : https://hal.archives-ouvertes.fr/pasteur-00655436

A. Santos, C. Figueira, M. Reis, F. Costa, and P. Ristow, Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology], pp.1161-1165, 2015.

P. Ristow, P. Bourhy, S. Kerneis, C. Schmitt, M. Prevost et al., Biofilm formation by saprophytic and pathogenic leptospires, Microbiology, vol.154, issue.5, pp.1309-17014746, 2007.
DOI : 10.1099/mic.0.2007/014746-0

G. Trueba, S. Zapata, K. Madrid, P. Cullen, and D. Haake, Cell aggregation: a mechanism of pathogenic Leptospira to survive in fresh water, Int Microbiol, vol.7, issue.1, pp.35-40, 2004.

K. Kassegne, W. Hu, D. Ojcius, D. Sun, Y. Ge et al., Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species. The Journal of infectious diseases, pp.1105-1120, 2014.

B. Gesser, H. Leffers, T. Jinquan, C. Vestergaard, N. Kirstein et al., Identification of functional domains on human interleukin 10, Proceedings of the National Academy of Sciences, vol.94, issue.26, pp.14620-507, 1997.
DOI : 10.1073/pnas.94.26.14620

R. Zhang, Q. Li, P. Chuang, G. Lu, R. Liu et al., Regulation of Pathogenic Th17 Cell Differentiation by IL-10 in the Development of Glomerulonephritis, The American Journal of Pathology, vol.183, issue.2, pp.402-414, 2013.
DOI : 10.1016/j.ajpath.2013.05.001

J. Da-silva, E. Carvalho, C. Cisterna, A. Ching, A. Mattaraia et al., Induction of TNF-alfa and CXCL-2 mRNAs in different organs of mice infected with pathogenic Leptospira. Microb Pathog. 2012

D. Athanazio, C. Santos, A. Santos, F. Mcbride, and M. Reis, Experimental infection in tumor necrosis factor alpha receptor, interferon gamma and interleukin 4 deficient mice by pathogenic Leptospira interrogans, Acta Tropica, vol.105, issue.1, pp.95-103, 2008.
DOI : 10.1016/j.actatropica.2007.09.004

R. Fujita, N. Koizumi, H. Sugiyama, R. Tomizawa, R. Sato et al., Comparison of Bacterial Burden and Cytokine Gene Expression in Golden Hamsters in Early Phase of Infection with Two Different Strains of Leptospira interrogans, PLOS ONE, vol.79, issue.7, p.4492770, 2015.
DOI : 10.1371/journal.pone.0132694.s008

P. Menten, A. Wuyts, and J. Van-damme, Macrophage inflammatory protein-1. Cytokine & growth factor reviews, pp.455-81, 2002.
DOI : 10.1016/s1359-6101(02)00045-x

T. Wada, H. Yokoyama, K. Matsushima, and K. Kobayashi, Chemokines in renal diseases, International Immunopharmacology, vol.1, issue.4, pp.637-682, 2001.
DOI : 10.1016/S1567-5769(01)00004-2

V. Vielhauer, E. Berning, V. Eis, M. Kretzler, S. Segerer et al., CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome, Kidney International, vol.66, issue.6, pp.2264-78, 2004.
DOI : 10.1111/j.1523-1755.2004.66038.x

L. Neville, G. Mathiak, and O. Bagasra, The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): A novel, pleiotropic member of the C-X-C chemokine superfamily, Cytokine & Growth Factor Reviews, vol.8, issue.3, pp.207-226, 1997.
DOI : 10.1016/S1359-6101(97)00015-4

M. Gomez-chiarri, A. Ortiz, S. Gonzalez-cuadrado, D. Seron, S. Emancipator et al., Interferon-inducible protein-10 is highly expressed in rats with experimental nephrosis. The American journal of pathology, PMID, vol.148, issue.1, pp.301-312, 1996.

S. Gonzalez-cuadrado, C. Bustos, M. Ruiz-ortega, A. Ortiz, C. Guijarro et al., Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis. Clinical and experimental immunology, Epub PMID, vol.10612, issue.3, pp.518-2201, 1996.

S. Segerer, B. Banas, M. Wornle, H. Schmid, C. Cohen et al., CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. The American journal of pathology, Epub, vol.16427, issue.20110, pp.635-684, 2004.
DOI : 10.1016/s0002-9440(10)63152-5

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602271

A. Lowanitchapat, S. Payungporn, A. Seeremaspun, P. Ekpo, D. Phulsuksombati et al., Expression of TNF-alpha, TGF-beta, IP-10 and IL-10 mRNA in kidneys of hamsters infected with pathogenic Leptospira Comparative immunology, microbiology and infectious diseases, pp.423-457, 2010.

D. Petrovic-djergovic, M. Popovic, S. Chittiprol, H. Cortado, R. Ransom et al., CXCL10 Induces the Recruitment of Monocyte Derived Macrophages into Kidney, which Aggravate Puromycin Aminonucleoside Nephrosis. Clinical and experimental immunology, 2015.

I. Nakaya, T. Wada, K. Furuichi, N. Sakai, K. Kitagawa et al., Blockade of IP-10/CXCR3 Promotes Progressive Renal Fibrosis, Nephron Experimental Nephrology, vol.107, issue.1, pp.12-21, 2007.
DOI : 10.1159/000106505

C. Mills, L. Lenz, and K. Ley, Macrophages at the fork in the road to health or disease. Frontiers in immunology, pp.59-4329822, 2015.

K. Furuichi, S. Kaneko, and T. Wada, Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease, Clinical and Experimental Nephrology, vol.165, issue.1, pp.9-14, 2008.
DOI : 10.1007/s10157-008-0119-5

H. Anders and M. Ryu, Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis, Kidney International, vol.80, issue.9, pp.915-940, 2011.
DOI : 10.1038/ki.2011.217

P. Wermuth and S. Jimenez, The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. Clinical and translational medicine, p.4384891, 2015.