Abstract : Movement variability is an essential characteristic of human movement. However , despite its prevalence, it is almost completely ignored in workstation design. Neglecting this variability can lead to skip over parts of the future opera-tor's movements, thus bring to incomplete assessment of biomechanical risk factors. This paper starts with a focus on movement variability in occupational activities. Then, as an example of feasibility, it describes a Digital Human Model framework intended to simulate the movement variability induced by muscle fatigue. The demonstrator is based on several simulation environments, namely 1) XDE, a virtual human simulation software tool previously used for ergonomics analyses, 2) a dynamic three-compartment model of muscle fatigue and recovery , and 3) OpenSim, a dynamic musculoskeletal simulation software. The demonstrator is a first step towards tools to assist designers in considering movement variability for improved ergonomics at the workstation.