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Article Dans Une Revue Journal of Magnetism and Magnetic Materials Année : 2017

Using injection molding and reversible bonding for easy fabrication of magnetic cell trapping and sorting devices

Résumé

Magnetism and microfluidics are two key elements for the development of inexpensive and reliable tools dedicated to high-throughput biological analysis and providing a large panel of applications in domains ranging from fundamental biology to medical diagnostics. In this work, we introduce a simple protocol, relying on injection molding and reversible bonding for fabrication of magnetic cell trapping and sorting devices using only standard soft-lithography equipment. Magnetic strips or grids made of Polydimethylsiloxane (PDMS) doped with hard (NdFeB) or soft (carbonyl iron) magnetic powders were integrated at the bottom of whole PDMS chips. Preliminary results show the effective deviation/trapping of magnetic beads or magnetically-labeled bacteria as the sample flows through the microchannel, proving the potential of this rapid prototyping approach for easy fabrication of magnetic cell sorters.
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Dates et versions

hal-01389920 , version 1 (30-10-2016)

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David Royet, Yoann Hériveaux, Julien Marchalot, Riccardo Scorretti, André Dias, et al.. Using injection molding and reversible bonding for easy fabrication of magnetic cell trapping and sorting devices. Journal of Magnetism and Magnetic Materials, 2017, 427, pp.306-313. ⟨10.1016/j.jmmm.2016.10.102⟩. ⟨hal-01389920⟩
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