Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Tulio Guadalupe 1, 2 Samuel R. Mathias 3 Theo G. M. Vanerp 4 Christopher D. Whelan 5 Marcel P. Zwiers 6 Yoshinari Abe 7 Lucija Abramovic 8 Ingrid Agartz 9 Ole A. Andreassen 10 Alejandro Arias-Vásquez 11, 12 Benjamin S. Aribisala 13, 14 Nicola J. Armstrong 15 Volker Arolt 16 Eric Artiges 17 Rosa Ayesa-Arriola 18, 19 Vatche G. Baboyan 20 Tobias Banaschewski 21 Gareth Barker 22 Mark E. Bastin 13 Bernhard T. Baune 23 John Blangero 24, 25 Arun L.W. Bokde 26 Premika S.W. Boedhoe 27 Anushree Bose 28 Silvia Brem 29 Henry Brodaty 30, 31 Uli Bromberg 32 Samantha Brooks Christian Büchel 32 Jan Buitelaar 33 Vince D. Calhoun 34, 35 Dara M. Cannon 36 Anna Cattrell 37 Yuqi Cheng 38 Patricia J. Conrod 37 Anne Conzelmann 39 Aiden Corvin 40, 41 Benedicto Crespo-Facorro 19 Fabrice Crivello 42 Udo Dannlowski 43 Greig I. de Zubicaray 44 Sonja M.C. de Zwarte 8 Ian J. Deary Sylvane Desrivières 37 Nhat Trung Doan Gary Donohoe 36, 41 Erlend S. Dørum 10 Stefan Ehrlich 45 Thomas Espeseth 46, 10 Guillén Fernández 47 Herta Flor 48 Paul Fouche 47 Vincent Frouin 49 Masaki Fukunaga 50 Jürgen Gallinat 51 Hugh Hu 47 Michael Gill 52 Andrea Gonzalez Suarez 47 Penny Gowland 53 Hans J. Grabe 54 Dominik Grotegerd 43 Oliver Gruber 47 Saskia Hagenaars 47 Ryota Hashimoto 55 Tobias U. Hauser 56 Andreas Heinz 47 Derrek P. Hibar 5 Pieter J. Hoekstra 57 Martine Hoogman 6 Fleur M. Howells 47 Hao Hu 47 Hilleke E. Hulshoff Pol 8 Chaim Huyser 47 Bernd Ittermann 51 Neda Jahanshad 5 Erik G. Jönsson 58 Sarah Jurk 47 Rene S. Kahn 59 Sinead Kelly 60 Bernd Kraemer 61 Harald Kugel 43 Jun Soo Kwon 62 Herve Lemaitre 63 Klaus-Peter Lesch 64 Christine Lochner 47 Michelle Luciano 65 Andre F. Marquand 66 Nicholas G. Martin Ignacio Martínez-Zalacaín 47 Jean-Luc Martinot 67, 68 David Mataix-Cols 47 Karen Mather 69 Colm Mcdonald 70 Katie L. Mcmahon 71 Sarah E. Medland 72 José M. Menchón 73, 74 Derek W. Morris 75 Omar Mothersill 47 Susana Munoz Maniega 47 Benson Mwangi 47 Takashi Nakamae 47 Tomohiro Nakao 47 Janardhanan C. Narayanaswaamy 47 Frauke Nees 21 Jan E. Nordvik 76, 77 A. Marten H. Onnink 47 Nils Opel 47 Roel Ophoff 78 Marie-Laure Paillère Martinot 67 Dimitri Papadopoulos 49 Paul Pauli 47 Tomáš Paus 79 Luise Poustka 48 Janardhan Yc. Reddy 80 Miguel E. Renteria 81 Robert Roiz-Santiáñez 19 Annerine Roos 82 Natalie A. Royle 13 Perminder Sachdev 83 Pascual Sánchez-Juan 84 Lianne Schmaal 85 Gunter Schumann 86 Elena Shumskaya 47 Michael N. Smolka 87 Jair C. Soares 88 Carles Soriano-Mas 89 Dan J. Stein 90 Lachlan T. Strike 91, 92, 72 Roberto Toro 93 Jessica A. Turner 94 Nathalie Tzourio-Mazoyer 42 Anne Uhlmann 47 Maria Valdés Hernández 95 Odile A. Van den Heuvel 96 Dennis Van Der Meer 97 Neeltje E.M . Van Haren 8 Dick J. Veltman 85 Ganesan Venkatasubramanian 47 Nora C. Vetter 47 Daniella Vuletic 47 Susanne Walitza 16 Henrik Walter 51, 98 Esther Walton 99 Zhen Wang 100 Joanna Wardlaw 13 Wei Wen 101 Lars T. Westlye 46, 10 Robert Whelan 102 Katharina Wittfeld 103, 104 Thomas Wolfers 47 Margaret J. Wright 105 Jian Xu 106 Xiufeng Xu 47 Je-Yeon Yun 107 Jingjing Zhao 47 Barbara Franke 33 Paul M. Thompson 20 David C. Glahn 108 Bernard Mazoyer 42 Simon E. Fisher 33 Clyde Francks 2, 6, 93
42 GIN - IMN UMR 5293 CNRS CEA Université de Bordeaux
IMN - Institut des Maladies Neurodégénératives [Bordeaux]
Abstract : The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
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Tulio Guadalupe, Samuel R. Mathias, Theo G. M. Vanerp, Christopher D. Whelan, Marcel P. Zwiers, et al.. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2017, 11 (5), pp.1497-1514. ⟨10.1007/s11682-016-9629-z⟩. ⟨hal-01382787⟩

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