Biaxial rupture properties of ascending thoracic aortic aneurysms

Ambroise Duprey (1, 2, 3, 4) , Olfa Trabelsi (1, 2, 4) , Marco Vola (3) , Jean-Pierre Favre (4, 2, 3) , Stéphane Avril (1, 2, 4)

1 SAINBIOSE - Santé Ingénierie Biologie Saint-Etienne
2 Université de Lyon
3 Service de Chirurgie cardiovasculaire [CHU Saint-Etienne]
4 LBTO - Biologie Intégrative du Tissu Osseux

Although hundreds of samples obtained from ascending thoracic aortic aneurysms (ATAA) of patients undergoing elective surgical repair have already been characterized biomechanically, their rupture properties were always derived from uniaxial tensile tests. Due to their bulge shape, ATAAs are stretched biaxially in vivo. In order to understand the biaxial rupture of ATAAs, our group developed a novel methodology based on bulge inflation and full-field optical measurements. The objective of the current paper is threefold. Firstly, we will review the failure properties (maximum stress, maximum stretch) obtained by bulge inflation testing on a cohort of 31 patients and compare them with failure properties obtained by uniaxial tension in a previously published study. Secondly, we will investigate the relationship between the failure properties and the age of patients, showing that patients below 55 years of age display significantly higher strength. Thirdly, we will define a rupture risk based on the extensibility of the tissue and we will show that this rupture risk is strongly correlated with the physiological elastic modulus of the tissue independently of the age, ATAA diameter or the aortic valve phenotype of the patient.

Mots clés: aneurysm; human thoracic aorta; bulge inflation test; rupture properties; extensibility

Domaines: Biomécanique [physics.med-ph]

Ambroise Duprey, Olfa Trabelsi, Marco Vola, Jean-Pierre Favre, Stéphane Avril. Biaxial rupture properties of ascending thoracic aortic aneurysms. Acta Biomaterialia, 2016. ⟨hal-01380216⟩