Reliability of PET/CT shape and heterogeneity features in functional and morphological components of Non-Small Cell Lung Cancer tumors: a repeatability analysis in a prospective multi-center cohort

Abstract : Purpose: The main purpose of this study was to assess the reliability of shape and heterogeneity features in both Positron Emission Tomography (PET) and low-dose Computed Tomography (CT) components of PET/CT. A secondary objective was to investigate the impact of image quantization. Material and methods: A Health Insurance Portability and Accountability Act -compliant secondary analysis of deidentified prospectively acquired PET/CT test-retest datasets of 74 patients from multi-center Merck and ACRIN trials was performed. Metabolically active volumes were automatically delineated on PET with Fuzzy Locally Adaptive Bayesian algorithm. 3DSlicerTM was used to semi-automatically delineate the anatomical volumes on low-dose CT components. Two quantization methods were considered: a quantization into a set number of bins (quantizationB) and an alternative quantization with bins of fixed width (quantizationW). Four shape descriptors, ten first-order metrics and 26 textural features were computed. Bland-Altman analysis was used to quantify repeatability. Features were subsequently categorized as very reliable, reliable, moderately reliable and poorly reliable with respect to the corresponding volume variability. Results: Repeatability was highly variable amongst features. Numerous metrics were identified as poorly or moderately reliable. Others were (very) reliable in both modalities, and in all categories (shape, 1st-, 2nd- and 3rd-order metrics). Image quantization played a major role in the features repeatability. Features were more reliable in PET with quantizationB, whereas quantizationW showed better results in CT. Conclusion: The test-retest repeatability of shape and heterogeneity features in PET and low-dose CT varied greatly amongst metrics. The level of repeatability also depended strongly on the quantization step, with different optimal choices for each modality. The repeatability of PET and low-dose CT features should be carefully taken into account when selecting metrics to build multiparametric models.
Liste complète des métadonnées

Littérature citée [35 références]  Voir  Masquer  Télécharger

https://hal.archives-ouvertes.fr/hal-01376668
Contributeur : Mathieu Hatt <>
Soumis le : mercredi 5 octobre 2016 - 14:20:09
Dernière modification le : jeudi 6 octobre 2016 - 09:37:35
Document(s) archivé(s) le : vendredi 6 janvier 2017 - 13:22:22

Fichiers

Manuscript_HAL.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : hal-01376668, version 1
  • ARXIV : 1610.01390

Collections

Citation

Marie-Charlotte Desseroit, Florent Tixier, Wolfgang Weber, Barry A Siegel, Catherine Cheze Le Rest, et al.. Reliability of PET/CT shape and heterogeneity features in functional and morphological components of Non-Small Cell Lung Cancer tumors: a repeatability analysis in a prospective multi-center cohort. Journal of Nuclear Medicine, Society of Nuclear Medicine, 2016. 〈hal-01376668〉

Partager

Métriques

Consultations de la notice

431

Téléchargements de fichiers

112