Skip to Main content Skip to Navigation
Journal articles

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses

Abstract : Polyamines are small, positively charged molecules derived from ornithine and synthesized through an intricately regulated enzymatic pathway. Within cells, they are abundant and play several roles in diverse processes. We find that polyamines are required for the life cycle of the RNA viruses chikungunya virus (CHIKV) and Zika virus (ZIKV). Depletion of spermidine and spermine via type I interferon signaling-mediated induction of spermidine/spermine N1-ace-tyltransferase (SAT1), a key catabolic enzyme in the polyamine pathway, restricts CHIKV and ZIKV replication. Polyamine depletion restricts these viruses in vitro and in vivo, due to impairment of viral translation and RNA replication. The restriction is released by exogenous replenishment of polyamines, further supporting a role for these molecules in virus replication. Thus, SAT1 and, more broadly, polyamine depletion restrict viral replication and suggest promising avenues for antiviral therapies.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-01373232
Contributor : Marco Vignuzzi Connect in order to contact the contributor
Submitted on : Wednesday, September 28, 2016 - 12:36:46 PM
Last modification on : Tuesday, October 19, 2021 - 10:28:53 PM

Links full text

Identifiers

Citation

Bryan c. Mounce, Enzo z. Poirier, Gabriella Passoni, Etienne Simon-Loriere, Teresa Cesaro, et al.. Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses. Cell Host and Microbe, Elsevier, 2016, 20 (2), pp.167-177. ⟨10.1016/j.chom.2016.06.011⟩. ⟨hal-01373232⟩

Share

Metrics

Record views

506