Probing the kinetics of lipid membrane formation and the interaction of a nontoxic and a toxic amyloid with plasmon waveguide resonance

Etienne Harté (1) , Nazek Maalouli (2) , Atef Shalabney (3) , Emmanuel Texier (4) , Karine Berthelot (5, 6) , Sophie Lecomte (1) , Isabel D. Alves (1)

1 CBMN - Chimie et Biologie des Membranes et des Nanoobjets
2 Univ Santiago Chile, Dept Quim Mat
3 ISIS - Institut de Science et d'ingénierie supramoléculaires
4 CRPP - Centre de recherches Paul Pascal
5 LCPO - Laboratoire de Chimie des Polymères Organiques
6 Team 1 LCPO : Polymerization Catalyses & Engineering

The kinetics of formation of solid-supported lipid model membranes were investigated using a home-made plasmon waveguide resonance (PWR) sensor possessing enhanced properties relative to classic surface plasmon resonance sensors. Additionally, the kinetics of interaction of two amyloid peptides with zwitterionic and anionic membranes and their effect on lipid organization were followed.

Mots clés: MUTANT; PROTEINS; ANISOTROPY; MICRODOMAINS; FILMS; RECEPTOR; TRANSDUCIN BINDING; SPECTROSCOPY; SOLID-SUPPORTED BILAYERS; LATERAL SEGREGATION

Domaines: Polymères

Etienne Harté, Nazek Maalouli, Atef Shalabney, Emmanuel Texier, Karine Berthelot, et al.. Probing the kinetics of lipid membrane formation and the interaction of a nontoxic and a toxic amyloid with plasmon waveguide resonance. Chemical Communications, 2014, 50 (32), pp.4168-4171. ⟨10.1039/c4cc00571f⟩. ⟨hal-01373075⟩