Slit-Robo signaling

Heike Blockus (1, 2) , Alain Chédotal (2)

1 ENP - Ecole des Neurosciences de Paris Île de France
2 Institut de la Vision

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. Here, we summarize new insights into Slit-Robo evolutionary and system-dependent diversity, receptor-ligand interactions, signaling crosstalk and receptor activation.

Mots clés: Migration; Development; Robo; Slit; Angiogenesis; Axon guidance

Domaines: Neurobiologie; Embryologie et organogenèse

Heike Blockus, Alain Chédotal. Slit-Robo signaling. Development (Cambridge, England), 2016, 143 (17), pp.3037-3044. ⟨10.1242/dev.132829⟩. ⟨hal-01372553⟩