Multivalent effect of glycopolypeptide based nanoparticles for galectin binding

Colin V. Bonduelle (1, 2) , Hugo de Oliveira (1, 3) , Cony Gauche Gauche (1) , Jin Huang (4) , Andreas Heise (4, 5) , Sébastien Lecommandoux (1, 6)

1 LCPO - Laboratoire de Chimie des Polymères Organiques
2 LCC - Laboratoire de chimie de coordination
3 INSERM, U1026, Tissue Bioengn, Univ Bordeaux
4 Dublin City Univ, Sci Chem Sci
5 Pol Chem & Biomat Lab, Dept Pharmaceut & Med Chem, Dublin
6 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies.

Domaines: Polymères

Colin V. Bonduelle, Hugo de Oliveira, Cony Gauche Gauche, Jin Huang, Andreas Heise, et al.. Multivalent effect of glycopolypeptide based nanoparticles for galectin binding. Chemical Communications, 2016, 52 (75), pp.11251-11254. ⟨10.1039/c6cc06437j⟩. ⟨hal-01372522⟩