Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy

Fares Bassil (1) , Pierre-Olivier Fernagut (1) , Erwan Bezard (1) , Alain Pruvost (2) , Thierry Leste-Lasserre (3) , Dagmar Ringe (4) , Gregory A. Petsko (4) , Quyen Hoang (5)

1 IMN - Institut des Maladies Neurodégénératives [Bordeaux]
2 LERI - Laboratoire d'Etudes et de Recherches en Immunoanalyses
3 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
4 Brandeis University
5 Indiana University School of Medicine

Domaines: Sciences du Vivant [q-bio]

Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Alain Pruvost, Thierry Leste-Lasserre, et al.. Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (34), ⟨10.1073/pnas.1609291113⟩. ⟨hal-01370967⟩