Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

Colin V. Bonduelle (1) , Jin Huang (2) , Teresa Mena Barragán (3) , Carmen Ortiz Mellet (3) , Camille Decroocq (4, 5) , Emile Etame (4, 5) , Andreas Heise (2) , Philippe Compain (4, 5, 6) , Sébastien Lecommandoux (1, 7)

1 LCPO - Laboratoire de Chimie des Polymères Organiques
2 Dublin City Univ, Sci Chem Sci
3 Univ Seville, Fac Chem, Dept Organ Chem
4 Univ Strasbourg, Lab Synth Orgn & Mol Bioact
5 LCM - Laboratoire de chimie moléculaire
6 IUF - Institut universitaire de France
7 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkablemultivalency properties when inhibiting alpha-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

Mots clés: RING-OPENING POLYMERIZATION; CLICK CLUSTERS; MULTIVALENT; FUNCTIONALIZATION; GLYCOPOLYMERS; GLYCOPEPTIDES; GLYCOBIOLOGY; POLYPEPTIDES; LECTINS; BINDING

Domaines: Polymères

Colin V. Bonduelle, Jin Huang, Teresa Mena Barragán, Carmen Ortiz Mellet, Camille Decroocq, et al.. Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies . Chemical Communications, 2014, 50 (25), pp.3350-3352. ⟨10.1039/c3cc48190e⟩. ⟨hal-01370005⟩