Skip to Main content Skip to Navigation
Journal articles

Mechanical behaviour'sevolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation

Abstract : PLA-b-PEG-b-PLA is a biodegradable triblock copolymer that presents both the mechanical properties of PLA and the hydrophilicity of PEG. In this paper, physical and mechanical properties of PLA-b-PEG-b-PLA are studied during in vitro degradation. The degradation process leads to a mass loss, a decrease of number average molecular weight and an increase of dispersity index. Mechanical experiments are made in a specific experimental set-up designed to create an environment close to in vivo conditions. The viscoelastic behaviour of the material is studied during the degradation. Finally, the mechanical behaviour is modelled with a linear viscoelastic model. A degradation variable is defined and included in the model to describe the hydrolytic degradation. This variable is linked to physical parameters of the macromolecular polymer network. The model allows us to describe weak deformations but become less accurate for larger deformations. The abilities and limits of the model are discussed.
Document type :
Journal articles
Complete list of metadatas

Cited literature [29 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01369301
Contributor : Benjamin Nottelet <>
Submitted on : Friday, November 9, 2018 - 4:19:15 PM
Last modification on : Friday, July 10, 2020 - 2:42:07 PM
Document(s) archivé(s) le : Sunday, February 10, 2019 - 3:02:17 PM

File

breche2016.pdf
Files produced by the author(s)

Identifiers

Citation

Quentin Breche, Grégory Chagnon, Guilherme Machado, Edouard Girard, Benjamin Nottelet, et al.. Mechanical behaviour'sevolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation. Journal of the mechanical behavior of biomedical materials, Elsevier, 2016, 60, pp.288-300. ⟨10.1016/j.jmbbm.2016.02.015⟩. ⟨hal-01369301⟩

Share

Metrics

Record views

397

Files downloads

286