Development of a novel isoniazid-membrane-field-effect transistor

Safae Merzouk (1) , Michael Lee (1) , Nicole Jaffrezic-Renault (2) , Abdelhamid Errachid (1) , Nadia Zine (1) , Joan Bausells (3) , Clara Vinas (4) , Francesc Teixidor (4)

1 ISA-Micro & Nanobiotechnologies
2 ISA-Interfaces & biosensors - Interfaces & biocapteurs
3 IMB-CNM - Instituto de Microelectrònica de Barcelona
4 ICMAB - Institut de Ciència de Materials de Barcelona

The Isoniazid (INH) sensing Membrane-Sensitive Field-Effect Transistor (MEMFET) device was developed. The optimized INH membrane was composed from a complex mixture of 7% (w/w) ion pair [H3-INH][Co(C2B9H11)2]3, 30% (w/w) polymer (polyvinyl chloride) (PVC), and 63% (w/w) of plasticizing agent o-nitrophenyloctyl ether (NPOE) which was dissolved in tetrahydrofuran (THF) solution. The potentiometric response was evaluated. The device exhibited excellent selectivity and a linear response over the concentration range from 3×10-6 M to 1×10-1 M with a slope of 55 ± 0.2 mV/decade. The INHMEMFETs are suitable for use with aqueous solutions of pH 9.5-5 and were found insensitive to the other antituberculosis (Sulfanilamide, Rifampicin, Ethambutol and pyrazinecarboxamide).

Mots clés: Microsensors; Electrodes; Transistors; Actuators; Instruments; Logic gates; Chemicals

Domaines: Chimie analytique

Safae Merzouk, Michael Lee, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Nadia Zine, et al.. Development of a novel isoniazid-membrane-field-effect transistor. SENSORS 2014 IEEE, Nov 2014, Valencia, Spain. pp.1104-1106, ⟨10.1109/ICSENS.2014.6985198⟩. ⟨hal-01363711⟩