Skip to Main content Skip to Navigation
Journal articles

Aortic Function's Adaptation in Response to Exercise-Induced Stress Assessing by 1.5T MRI : A Pilot Study in Healthy Volunteers

Abstract : Evaluation of the aortic "elastic reserve" might be a relevant marker to assess the risk of aortic event. Our aim was to compare regional aortic elasticity at rest and during supine bicycle exercise at 1.5 T MRI in healthy individuals. Fifteen volunteers (8 men), with a mean age of 29 (23-41) years, completed the entire protocol. Images were acquired immediately following maximal exercise. Retrospective cine sequences were acquired to assess compliance, distensibility, maximum rates of systolic distension and diastolic recoil at four different locations: ascending aorta, proximal descending aorta, distal descending aorta and aorta above the coeliac trunk level. Segmental aortic pulse wave velocity (PWV) was assessed by through plane velocity-encoded MRI. Exercise induced a significant decrease of aortic compliance and distensibility, and a significant increase of the absolute values of maximum rates of systolic distension and diastolic recoil at all sites (p<10-3). At rest and during stress, ascending aortic compliance was statistically higher compared to the whole descending aorta (p≤0.0007). We found a strong correlation between the rate pressure product and aortic distensibility at all sites (r = - 0.6 to -0.75 according to the site, p<10-4). PWV measured at the proximal and distal descending aorta increased significantly during stress (p = 0.02 and p = 0.008, respectively). Assessment of regional aortic function during exercise is feasible using MRI. During stress, aortic elasticity decreases significantly in correlation with an increase of the PWV. Further studies are required to create thresholds for ascending aorta dysfunction among patients with aneurysms, and to monitor the impact of medication on aortic remodeling.
Complete list of metadatas

Cited literature [34 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01362479
Contributor : Alain Lalande <>
Submitted on : Thursday, September 20, 2018 - 12:05:47 PM
Last modification on : Monday, March 30, 2020 - 8:55:34 AM
Document(s) archivé(s) le : Friday, December 21, 2018 - 2:02:04 PM

File

journal.pone.0157704.PDF
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Laurence Bal-Theoleyre, Alain Lalande, Frank Kober, Roch Giorgi, Frederic Collart, et al.. Aortic Function's Adaptation in Response to Exercise-Induced Stress Assessing by 1.5T MRI : A Pilot Study in Healthy Volunteers. PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0157704. ⟨10.1371/journal.pone.0157704⟩. ⟨hal-01362479⟩

Share

Metrics

Record views

373

Files downloads

474