L. Ling, T. Schneider, A. Peoples, A. Spoering, I. Engels et al., A new antibiotic kills pathogens without detectable resistance, Nature, vol.16, issue.7535, pp.455-459, 2015.
DOI : 10.1038/nature14098

M. Lauterwein, M. Oethinger, K. Belsner, T. Peters, and R. Marre, In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms, Antimicrobial Agents and Chemotherapy, vol.39, issue.11, pp.2541-2543, 1995.
DOI : 10.1128/AAC.39.11.2541

K. Ingolfsdottir and . Usnic, Usnic acid, Phytochemistry, vol.61, issue.7, pp.729-736, 2002.
DOI : 10.1016/S0031-9422(02)00383-7

K. Molnar and E. Farkas, Current Results on Biological Activities of Lichen Secondary Metabolites: a Review, Zeitschrift f??r Naturforschung C, vol.65, issue.3-4, pp.157-173, 2010.
DOI : 10.1515/znc-2010-3-401

G. Shrestha, . St, and L. Clair, Lichens: a promising source of antibiotic and anticancer drugs, Phytochemistry Reviews, vol.22, issue.1, pp.229-244, 2013.
DOI : 10.1007/s11101-013-9283-7

V. Shukla, G. Joshi, and M. Rawat, Lichens as a potential natural source of bioactive compounds: a review, Phytochemistry Reviews, vol.2, issue.6, pp.303-314, 2010.
DOI : 10.1007/s11101-010-9189-6

J. Boustie and M. Grube, Lichens???a promising source of bioactive secondary metabolites, Plant Genetic Resources: Characterization and Utilization, vol.55, issue.02, pp.273-287, 2005.
DOI : 10.1111/j.1432-1033.2004.03981.x

J. Boustie, S. Tomasi, and M. Grube, Bioactive lichen metabolites: alpine habitats as an untapped source, Phytochemistry Reviews, vol.308, issue.9, pp.287-307, 2011.
DOI : 10.1007/s11101-010-9201-1
URL : https://hal.archives-ouvertes.fr/hal-00843547

D. Hawksworth, The lichenicolous fungi of Great Britain and Ireland: an overview and annotated checklist, The Lichenologist, vol.35, issue.3, pp.191-232, 2003.
DOI : 10.1016/S0024-2829(03)00027-6

J. Lawrey and P. Diederich, Lichenicolous Fungi: Interactions, Evolution, and Biodiversity, The Bryologist, vol.106, issue.1, pp.80-120, 2003.
DOI : 10.1639/0007-2745(2003)106[0080:LFIEAB]2.0.CO;2

I. González, A. Ayuso-sacido, A. Anderson, and O. Genilloud, Actinomycetes isolated from lichens: Evaluation of their diversity and detection of biosynthetic gene sequences, FEMS Microbiology Ecology, vol.54, issue.3, pp.401-415, 2005.
DOI : 10.1016/j.femsec.2005.05.004

M. Cardinale, A. Puglia, and M. Grube, Molecular analysis of lichen-associated bacterial communities, FEMS Microbiology Ecology, vol.57, issue.3, pp.484-495, 2006.
DOI : 10.1111/j.1574-6941.2006.00133.x

M. Cardinale, G. Berg, M. Grube, J. Vieira-de-castro, and H. Müller, In situ analysis of the bacterial community associated with the reindeer lichen Cladonia arbuscula reveals predominance of Alphaproteobacteria, FEMS Microbiology Ecology, vol.66, issue.1, pp.63-71, 2008.
DOI : 10.1111/j.1574-6941.2008.00546.x

M. Cardinale, M. Grube, J. Castro, H. Müller, and G. Berg, Bacterial taxa associated with the lung lichen Lobaria pulmonaria are differentially shaped by geography and habitat, FEMS Microbiology Letters, vol.329, issue.2, pp.111-115, 2012.
DOI : 10.1111/j.1574-6968.2012.02508.x

C. Liba, F. Ferrara, G. Manfio, F. Fantinatti-garboggini, R. Albuquerque et al., Nitrogen-fixing chemo-organotrophic bacteria isolated from cyanobacteria-deprived lichens and their ability to solubilize phosphate and to release amino acids and phytohormones, Journal of Applied Microbiology, vol.46, issue.5, pp.1076-1086, 2006.
DOI : 10.1007/BF02226804

M. Grube and G. Berg, Microbial consortia of bacteria and fungi with focus on the lichen symbiosis, Fungal Biology Reviews, vol.23, issue.3, pp.72-85, 2009.
DOI : 10.1016/j.fbr.2009.10.001

M. Grube, M. Cardinale, J. De-castro-jr, H. Müller, and G. Berg, Species-specific structural and functional diversity of bacterial communities in lichen symbioses, The ISME Journal, vol.64, issue.9, pp.1105-1115, 2009.
DOI : 10.1126/science.1111347

B. Hodkinson and F. Lutzoni, A microbiotic survey of lichen-associated bacteria reveals a new lineage from the Rhizobiales, Symbiosis, vol.6, issue.3, pp.163-180, 2009.
DOI : 10.1007/s13199-009-0049-3

S. Bates, G. Cropsey, J. Caporaso, R. Knight, and N. Fierer, Bacterial Communities Associated with the Lichen Symbiosis, Applied and Environmental Microbiology, vol.77, issue.4, pp.1309-1314, 2011.
DOI : 10.1128/AEM.02257-10

L. Muggia, L. Vancurova, P. Skaloud, O. Peksa, M. Wedin et al., The symbiotic playground of lichen thalli - a highly flexible photobiont association in rock-inhabiting lichens, FEMS Microbiology Ecology, vol.85, issue.2, pp.313-323, 2013.
DOI : 10.1111/1574-6941.12120

M. Grube, T. Cernava, J. Soh, S. Fuchs, I. Aschenbrenner et al., Exploring functional contexts of symbiotic sustain within lichen-associated bacteria by comparative omics, The ISME Journal, vol.5, issue.2, pp.1-13, 2015.
DOI : 10.1038/ismej.2014.138

M. Cardinale, J. Steinová, J. Rabensteiner, G. Berg, and M. Grube, Age, sun and substrate: triggers of bacterial communities in lichens, Environmental Microbiology Reports, vol.11, issue.1, pp.23-28, 2012.
DOI : 10.1111/j.1758-2229.2011.00272.x

M. Grube, G. Berg, Ó. Andrésson, O. Vilhelmsson, P. Dyer et al., Lichen Genomics, pp.191-212
DOI : 10.1002/9781118735893.ch9

T. Bjelland, M. Grube, S. Hoem, S. Jorgensen, F. Daae et al., Microbial metacommunities in the lichen-rock habitat, Environmental Microbiology Reports, vol.73, issue.4, pp.434-442, 2011.
DOI : 10.1111/j.1758-2229.2010.00206.x

S. An, X. T. Yokota, and A. , Leifsonia lichenia sp. nov., isolated from lichen in Japan, The Journal of General and Applied Microbiology, vol.55, issue.5, pp.339-343, 2009.
DOI : 10.2323/jgam.55.339

S. An, X. T. Yokota, and A. , Schumannella luteola gen. nov., sp. nov., a novel genus of the family Microbacteriaceae, The Journal of General and Applied Microbiology, vol.54, issue.5, pp.253-258, 2008.
DOI : 10.2323/jgam.54.253

S. Cheenpracha, N. Vidor, W. Yoshida, J. Davies, and L. Chang, sp. L-4-4, Journal of Natural Products, vol.73, issue.5, pp.880-884, 2010.
DOI : 10.1021/np900843b

J. Davies, H. Wang, T. Taylor, K. Warabi, X. Huang et al., Uncialamycin, A New Enediyne Antibiotic, Organic Letters, vol.7, issue.23, pp.5233-5236, 2005.
DOI : 10.1021/ol052081f

B. Li, C. Xie, and A. Yokota, Nocardioides exalbidus sp. nov., a novel actinomycete isolated from lichen in Izu-Oshima Island, Japan, Actinomycetologica, vol.21, issue.1, pp.22-26, 2007.
DOI : 10.3209/saj.SAJ210103

K. Motohashi, M. Takagi, H. Yamamura, M. Hayakawa, and K. Shin-ya, A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp., The Journal of Antibiotics, vol.92, issue.9, pp.545-548, 2010.
DOI : 10.1111/j.1574-6968.1995.tb07387.x

L. Selbmann, L. Zucconi, S. Ruisi, M. Grube, M. Cardinale et al., Culturable bacteria associated with Antarctic lichens: affiliation and psychrotolerance, Polar Biology, vol.16, issue.9, pp.71-83, 2009.
DOI : 10.1007/s00300-009-0686-2

A. Cladoniamides, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis, Org Lett, vol.10, pp.3501-3504, 2008.

D. Parrot, S. Antony-babu, L. Intertaglia, M. Grube, S. Tomasi et al., Littoral lichens as a novel source of potentially bioactive Actinobacteria, Scientific Reports, vol.41, p.15839, 2015.
DOI : 10.1038/srep15839
URL : https://hal.archives-ouvertes.fr/hal-01230478

H. Yamamura, H. Ashizawa, Y. Nakagawa, M. Hamada, Y. Ishida et al., Actinomycetospora iriomotensis sp. nov., a novel actinomycete isolated from a lichen sample, The Journal of Antibiotics, vol.20, issue.4, pp.289-292, 2011.
DOI : 10.1099/00207713-37-4-463

M. Suzuki, D. Parrot, G. Berg, M. Grube, and S. Tomasi, Lichens as natural sources of biotechnologically relevant bacteria, Applied Microbiology and Biotechnology, vol.54, issue.2, pp.1-13, 2015.
DOI : 10.1007/s00253-015-7114-z
URL : https://hal.archives-ouvertes.fr/hal-01227960

B. Hodkinson, N. Gottel, C. Schadt, and F. Lutzoni, Photoautotrophic symbiont and geography are major factors affecting highly structured and diverse bacterial communities in the lichen microbiome, Environmental Microbiology, vol.16, issue.1, pp.147-161, 2012.
DOI : 10.1111/j.1462-2920.2011.02560.x

A. Mushegian, C. Peterson, C. Baker, and A. Pringle, Bacterial Diversity across Individual Lichens, Applied and Environmental Microbiology, vol.77, issue.12, pp.4249-4252, 2011.
DOI : 10.1128/AEM.02850-10

M. Sigurbjörnsdóttir, S. Heiðmarsson, A. Jónsdóttir, and O. Vilhelmsson, Novel bacteria associated with Arctic seashore lichens have potential roles in nutrient scavenging, Canadian Journal of Microbiology, vol.60, issue.5, pp.307-317, 2014.
DOI : 10.1139/cjm-2013-0888

Y. Navarro-noya, A. Jiménez-aguilar, C. Valenzuela-encinas, J. Alcántara-hernández, V. Ruíz-valdiviezo et al., Bacterial Communities in Soil Under Moss and Lichen-Moss Crusts, Geomicrobiology Journal, vol.17, issue.2, pp.152-160, 2014.
DOI : 10.1016/j.jaridenv.2010.04.006

J. Davies and K. Ryan, Introducing the Parvome: Bioactive Compounds in the Microbial World, ACS Chemical Biology, vol.7, issue.2, pp.252-259, 2012.
DOI : 10.1021/cb200337h

D. Williams, H. Bottriell, J. Davies, I. Tietjen, M. Brockman et al., Unciaphenol, an oxygenated analogue of the Bergman cyclization product of uncialamycin exhibits anti-HIV activity, Org Lett, pp.5304-5307, 2015.

M. Cardinale, M. Grube, and G. Berg, Frondihabitans cladoniiphilus sp. nov., an actinobacterium of the family Microbacteriaceae isolated from lichen, and emended description of the genus Frondihabitans, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, vol.61, issue.12, pp.3033-3038, 2011.
DOI : 10.1099/ijs.0.028324-0

S. Singh, G. Garrity, O. Genillourd, R. Lingham, I. Martin et al., Inhibitor compounds of farnesyl-protein transferase and chemotherapeutic compositions containing the same, produced by strain ATCC 55532, p.57, 1997.

A. Braña, H. Fiedler, H. Nava, V. González, A. Sarmiento-vizcaíno et al., Two Streptomyces Species Producing Antibiotic, Antitumor, and Anti-Inflammatory Compounds Are Widespread Among Intertidal Macroalgae and Deep-Sea Coral Reef Invertebrates from the Central Cantabrian Sea, Microbial Ecology, vol.158, issue.3, pp.512-524, 2015.
DOI : 10.1007/s00248-014-0508-0

Y. Takahashi and S. Omura, Isolation of new actinomycete strains for the screening of new bioactive compounds., The Journal of General and Applied Microbiology, vol.49, issue.3, pp.141-154, 2003.
DOI : 10.2323/jgam.49.141

B. Murphy, P. Jensen, W. Fenical, E. Fattorusso, W. Gerwick et al., The Chemistry of Marine Bacteria, Handbook of Marine Natural Products, pp.153-190
DOI : 10.1007/978-90-481-3834-0_3

B. Waters, G. Saxena, Y. Wanggui, D. Kau, S. Wrigley et al., Identifying Protein Kinase Inhibitors Using an Assay Based on Inhibition of Aerial Hyphae Formation in Streptomyces., The Journal of Antibiotics, vol.55, issue.4, pp.407-416, 2002.
DOI : 10.7164/antibiotics.55.407

G. Yao, N. Vidor, A. Foss, and L. Chang, sp., Journal of Natural Products, vol.70, issue.6, pp.901-905, 2007.
DOI : 10.1021/np0603424
URL : https://hal.archives-ouvertes.fr/halsde-00611020

I. Raad, R. Hachem, D. Abi-said, K. Rolston, E. Whimbey et al., A prospective crossover randomized trial of novobiocin and rifampin prophylaxis for the prevention of intravascular catheter infections in cancer patients treated with interleukin-2, Cancer, vol.24, issue.2, pp.403-411, 1998.
DOI : 10.1002/(SICI)1097-0142(19980115)82:2<412::AID-CNCR22>3.0.CO;2-0

T. Walsh, H. Standiford, A. Reboli, J. John, M. Mulligan et al., Randomized double-blinded trial of rifampin with either novobiocin or trimethoprim-sulfamethoxazole against methicillin-resistant Staphylococcus aureus colonization: prevention of antimicrobial resistance and effect of host factors on outcome., Antimicrobial Agents and Chemotherapy, vol.37, issue.6, pp.1334-1342, 1993.
DOI : 10.1128/AAC.37.6.1334

M. Konishi, H. Ohkuma, T. Tsuno, and T. Oki, Crystal and molecular structure of dynemicin A: a novel 1,5-diyn-3-ene antitumor antibiotic, Journal of the American Chemical Society, vol.112, issue.9, pp.3715-3716, 1990.
DOI : 10.1021/ja00165a097

K. Nicolaou, J. Chen, H. Zhang, and A. Montero, Asymmetric Synthesis and Biological Properties of Uncialamycin and 26-epi-Uncialamycin, Angewandte Chemie International Edition, vol.95, issue.1, pp.185-189, 2008.
DOI : 10.1002/anie.200704577

M. Jean, S. Tomasi, and P. Van-de-weghe, When the nine-membered enediynes play hide and seek, Organic & Biomolecular Chemistry, vol.13, issue.37, pp.7453-7456, 2012.
DOI : 10.1039/c2ob26033f
URL : https://hal.archives-ouvertes.fr/hal-00841706

N. Damle, Tumour-targeted chemotherapy with immunoconjugates of calicheamicin, Expert Opinion on Biological Therapy, vol.56, issue.4, pp.1445-1452, 2004.
DOI : 10.1016/0008-8749(89)90359-6

M. Berger, L. Leopold, J. Dowell, J. Korth-bradley, and M. Sherman, Licensure of gemtuzumab ozogamicin for the treatment of selected patients 60 years of age or older with acute myeloid leukemia in first relapse, Investigational New Drugs, vol.20, issue.4, pp.395-406, 2002.
DOI : 10.1023/A:1020658028082

P. Hamann, L. Hinman, C. Beyer, L. Greenberger, C. Lin et al., An Anti-MUC1 Antibody???Calicheamicin Conjugate for Treatment of Solid Tumors. Choice of Linker and Overcoming Drug Resistance, Bioconjugate Chemistry, vol.16, issue.2, pp.346-353, 2005.
DOI : 10.1021/bc049795f

R. Bergman, Reactive 1,4-dehydroaromatics, Accounts of Chemical Research, vol.6, issue.1, pp.25-31, 1973.
DOI : 10.1021/ar50061a004

A. Myers, M. Fraley, N. Tom, S. Cohen, and D. Madar, Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the absolute configuration of natural dynemicin A, Chemistry & Biology, vol.2, issue.1, pp.33-43, 1995.
DOI : 10.1016/1074-5521(95)90078-0

A. Smith and K. Nicolaou, The Enediyne Antibiotics, Journal of Medicinal Chemistry, vol.39, issue.11, pp.2103-2117, 1996.
DOI : 10.1021/jm9600398

C. Sanchez, C. Mendez, and J. Salas, Indolocarbazole natural products: occurrence, biosynthesis, and biological activity, Nat. Prod. Rep., vol.45, issue.16S, pp.1007-1045, 2006.
DOI : 10.1039/B601930G

A. Howard-jones and C. Walsh, Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid, Journal of the American Chemical Society, vol.128, issue.37, pp.12289-12298, 2006.
DOI : 10.1021/ja063898m

C. Hyun, T. Bililign, J. Liao, and J. Thorson, The Biosynthesis of Indolocarbazoles in a Heterologous E. coli Host, ChemBioChem, vol.99, issue.1, pp.114-117, 2003.
DOI : 10.1002/cbic.200390004

C. Sánchez, C. Méndez, and J. Salas, Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives, Journal of Industrial Microbiology & Biotechnology, vol.12, issue.7, pp.560-568, 2006.
DOI : 10.1007/s10295-006-0092-5

C. Sánchez, L. Zhu, A. Braña, A. Salas, J. Rohr et al., From The Cover: Combinatorial biosynthesis of antitumor indolocarbazole compounds, Proceedings of the National Academy of Sciences, vol.102, issue.2, pp.461-466, 2005.
DOI : 10.1073/pnas.0407809102

C. Zhang, C. Albermann, X. Fu, N. Peters, J. Chisholm et al., RebG- and RebM-Catalyzed Indolocarbazole Diversification, ChemBioChem, vol.72, issue.5, pp.795-804, 2006.
DOI : 10.1002/cbic.200500504

S. Singh, J. Liesch, R. Lingham, M. Goetz, and J. Gibbst, Actinoplanic Acid A: A Macrocyclic Polycarboxylic Acid Which Is a Potent Inhibitor of Ras Farnesyl-Protein Transferase, Journal of the American Chemical Society, vol.116, issue.25, pp.11606-11607, 1994.
DOI : 10.1021/ja00104a066

K. Silverman, C. Cascales, O. Genilloud, S. J. Gartner, S. Koch et al., Actinoplanic acids A and B as novel inhibitors of farnesyl-protein transferase, Applied Microbiology and Biotechnology, vol.45, issue.4, pp.610-616, 1995.
DOI : 10.1007/BF00164762

A. Fernandez-medarde and E. Santos, Ras in Cancer and Developmental Diseases, Genes & Cancer, vol.2, issue.3, pp.344-358, 2011.
DOI : 10.1177/1947601911411084

K. Nicolaou, H. Zhang, J. Chen, J. Crawford, and L. Pasunoori, Total Synthesis and Stereochemistry of Uncialamycin, Angewandte Chemie International Edition, vol.6, issue.25, pp.4704-4707, 2007.
DOI : 10.1002/anie.200700917

H. Bretschneider, . Hohenlohe-oehringen, and A. Rhomberg, 3-acetyl-cinchoninic acid compounds, US Patent, vol.3632, p.311, 1967.

A. Fujii, S. Hashiguchi, N. Uematsu, T. Ikariya, and R. Noyori, Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using a Formic Acid???Triethylamine Mixture, Journal of the American Chemical Society, vol.118, issue.10, pp.2521-2522, 1996.
DOI : 10.1021/ja954126l

R. Noyori and S. Hashiguchi, Asymmetric Transfer Hydrogenation Catalyzed by Chiral Ruthenium Complexes, Accounts of Chemical Research, vol.30, issue.2, pp.97-102, 1997.
DOI : 10.1021/ar9502341

S. Desrat and P. Van-de-weghe, Intramolecular Imino Diels???Alder Reaction: Progress toward the Synthesis of Uncialamycin, The Journal of Organic Chemistry, vol.74, issue.17, pp.6728-6734, 2009.
DOI : 10.1021/jo901291t

S. Desrat, M. Jean, and P. Van-de-weghe, Setbacks and hopes: en route to the synthesis of uncialamycin, Tetrahedron, vol.67, issue.39, pp.7510-7516, 2011.
DOI : 10.1016/j.tet.2011.07.090
URL : https://hal.archives-ouvertes.fr/hal-00843821

A. Bartoszewicz, M. Kalek, and J. Stawinski, Iodine-promoted silylation of alcohols with silyl chlorides. Synthetic and mechanistic studies, Tetrahedron, vol.64, issue.37, pp.8843-8850, 2008.
DOI : 10.1016/j.tet.2008.06.070

A. Myers, N. Tom, M. Fraley, S. Cohen, and D. Madar, A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability, Journal of the American Chemical Society, vol.119, issue.26, pp.6072-6094, 1997.
DOI : 10.1021/ja9703741