Structure-function relationships of glycoprotein hormones and their subunits’ ancestors

Claire Cahoreau (1) , Danièle Klett (1) , Yves Combarnous (1)

1 PRC - Physiologie de la reproduction et des comportements [Nouzilly]

Glycoprotein hormones (GPHs) are the most complex molecules with hormonal activity. They exist only in vertebrates but the genes encoding their subunits’ ancestors are found in most vertebrate and invertebrate species although their roles are still unknown. In the present report, we review the available structural and functional data concerning GPHs and their subunits’ ancestors.

Mots clés: glycoprotein hormone; luteinizing hormone; follicle stimulating hormone; thyroid stimulating hormone; evolution; molecular; stucture activity relationship

Domaines: Autre [q-bio.OT]

Claire Cahoreau, Danièle Klett, Yves Combarnous. Structure-function relationships of glycoprotein hormones and their subunits’ ancestors. Frontiers in Endocrinology, 2015, 6, pp.1-14. ⟨10.3389/fendo.2015.00026⟩. ⟨hal-01351175⟩