A functional network involved in the recycling of nucleocytoplasmic pre-60S factors - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Cell Biology Année : 2006

A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

Résumé

Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in the cytoplasm of a small complex formed by the association of Arx1 with a novel factor, Alb1/Yjl122w, inhibits the release of the putative antiassociation factor Tif6 from the premature large ribosomal subunits and its recycling to the nucleus. We propose a model in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation.
Fichier principal
Vignette du fichier
Lebreton2006ci.pdf (13.32 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01350674 , version 1 (03-08-2016)

Identifiants

Citer

Alice Lebreton, Cosmin Saveanu, Laurence Decourty, Jean-Christophe Rain, Alain Jacquier, et al.. A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. Journal of Cell Biology, 2006, 173 (3), pp.349-60. ⟨10.1083/jcb.200510080⟩. ⟨hal-01350674⟩
111 Consultations
110 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More