A versatile fast-development platform applied to closed-loop diaphragmatic pacing

Adeline Zbrzeski (1) , Ricardo Siu (2) , Yannick Bornat (1) , Brian Hillen (2) , Ranu Jung (2) , Sylvie Renaud (1)

1 IMS - Laboratoire de l'intégration, du matériau au système
2 Biomedical Engineering Department

People with cervical spinal cord injury have partial or complete loss of ventilatory control and require ventilator assist. Open-loop diaphragmatic pacing can be utilized to provide this assist. A closed-loop diaphragmatic pacing system could overcome the drawbacks for manual titration of the stimulation and respond to changing ventilatory requirements. We have developed a versatile custom hardware platform dubbed " Multimed " for biosignal acquisition and parallel real-time computation, data display and storage. We have also developed a new rodent model for diaphragmatic pacing. Using these we illustrate, to our knowledge for the first-time, the successful ability to perform respiratory flow-phase triggered closed-loop diaphragmatic stimulation with resultant changes in respiratory flow and tidal volume.

Domaines: Micro et nanotechnologies/Microélectronique; Electronique; Ingénierie biomédicale

Adeline Zbrzeski, Ricardo Siu, Yannick Bornat, Brian Hillen, Ranu Jung, et al.. A versatile fast-development platform applied to closed-loop diaphragmatic pacing . 7th International IEEE/EMBS Conference on Neural Engineering (NER), Apr 2015, Montpellier, France. pp.791-794, ⟨10.1109/NER.2015.7146742⟩. ⟨hal-01347976⟩