An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents

Abstract : This paper describes a Deep Brain Stimulation device , portable, for chronic experiments on rodents in the context of Parkinson's disease. Our goal is to equip the animal with a device that mimics the human therapeutic conditions. It implies to respect a set of properties such as bilateral current-mode and charge-balanced stimulation, as well as programmability, low power consumption and re-usability to finally reach a suitable weight for long-term experiments. After the analysis of the solutions found in the literature, the full design of the device is explained. First, the stimulation front-end circuit driven by a processor unit, then the choice of supply sources which is a critical point for the weight and lifetime of our system. Our low cost system has been realized using commercial discrete components and the overall power consumption was minimized. We achieved 6 days of maximal current stimulation with the chosen battery for a weight of 13.8g. Finally, the device was carried out in vivo on rats during a 3 weeks experiment as the used implantation technique allows battery changing. This experiment also permits to emphasize the mechanical aspects including the packaging and electrodes holding.
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Florian Kolbl, Gilles N'Kaoua, Frederic Naudet, Florent Berthier, Emilie Faggiani, et al.. An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents. IEEE Transactions on Biomedical Circuits and Systems, IEEE, 2016, 10 (1), pp.72-84. ⟨10.1109/TBCAS.2014.2368788⟩. ⟨hal-01347597⟩

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