Bio-Inspired Controller on an FPGA Applied to Closed-Loop Diaphragmatic Stimulation

Abstract : Cervical spinal cord injury can disrupt connections between the brain respiratory network and the respiratory muscles which can lead to partial or complete loss of ventilatory control and require ventilatory assistance. Unlike current open-loop technology, a closed-loop diaphragmatic pacing system could overcome the drawbacks of manual titration as well as respond to changing ventilation requirements. We present an original bio-inspired assistive technology for real-time ventilation assistance, implemented in a digital configurable Field Programmable Gate Array (FPGA). The bio-inspired controller, which is a spiking neural network (SNN) inspired by the medullary respiratory network, is as robust as a classic controller while having a flexible, low-power and low-cost hardware design. The system was simulated in MATLAB with FPGA-specific constraints and tested with a computational model of rat breathing; the model reproduced experimentally collected respiratory data in eupneic animals. The open-loop version of the bio-inspired controller was implemented on the FPGA. Electrical test bench characterizations confirmed the system functionality. Open and closed-loop paradigm simulations were simulated to test the FPGA system real-time behavior using the rat computational model. The closed-loop system monitors breathing and changes in respiratory demands to drive diaphragmatic stimulation. The simulated results inform future acute animal experiments and constitute the first step toward the development of a neuromorphic, adaptive, compact, low-power, implantable device. The bio-inspired hardware design optimizes the FPGA resource and time costs while harnessing the computational power of spike-based neuromorphic hardware. Its real-time feature makes it suitable for in vivo applications.
Liste complète des métadonnées

Littérature citée [52 références]  Voir  Masquer  Télécharger

https://hal.archives-ouvertes.fr/hal-01347466
Contributeur : Yannick Bornat <>
Soumis le : jeudi 21 juillet 2016 - 10:04:21
Dernière modification le : vendredi 19 octobre 2018 - 11:36:02

Fichier

fnins-10-00275.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Adeline Zbrzeski, Yannick Bornat, Brian Hillen, Ricardo Siu, James Abbas, et al.. Bio-Inspired Controller on an FPGA Applied to Closed-Loop Diaphragmatic Stimulation. Frontiers in Neuroscience, Frontiers, 2016, 10, pp.275. 〈10.3389/fnins.2016.00275〉. 〈hal-01347466〉

Partager

Métriques

Consultations de la notice

127

Téléchargements de fichiers

137