Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns?

Julien Lefèvre; David Germanaud; Jessica Dubois; Ines de Macedo Santos; Hugo Angleys; Jean-Francois Mangin; Petra S. Huppi; Nadine Girard; Francois de Guio; François Rousseau

doi:10.1093/cercor/bhv123

Journal articles

Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns?

Julien Lefèvre ^{1, 2} David Germanaud ^{3, 4, 5, 6, 7} Jessica Dubois ^{5, 8, 9} Ines de Macedo Santos ⁵ Hugo Angleys ^{5, 8} Jean-Francois Mangin ⁵ Petra S. Huppi ^{10, 11} Nadine Girard ^{12, 13} Francois de Guio ^{5, 14} François Rousseau ^{15, 16}

1 LSIS - Laboratoire des Sciences de l'Information et des Systèmes

2 INT - Institut de Neurosciences de la Timone

3 Service de neurologie pédiatrique et maladies métaboliques

4 UPD7 - Université Paris Diderot - Paris 7

5 IFR49 - Neurospin - CEA

6 U1129 - Epilepsies de l'Enfant et Plasticité Cérébrale

7 UPD5 - Université Paris Descartes - Paris 5

8 UNICOG-U992 - Neuroimagerie cognitive - Psychologie cognitive expérimentale

9 UP11 - Université Paris-Sud - Paris 11

10 Department of Neurology, Children's Hospital [Boston]

11 Department of Pediatrics (Geneva University Hospitals)

12 CRMBM - Centre de résonance magnétique biologique et médicale

13 Service de neuroradiologie diagnostique et interventionnelle

14 U1161 / UMR_S 1161 - Génétique et Physiopathologie des Maladies Cérébro-Vasculaires

15 ITI - Département Image et Traitement Information

16 LaTIM - Laboratoire de Traitement de l'Information Medicale

Abstract : Magnetic resonance imaging has proved to be suitable and efficient for in vivo investigation of the early process of brain gyrification in fetuses and preterm newborns but the question remains as to whether cortical-related measurements derived from both cases are comparable or not. Indeed, the developmental folding trajectories drawn up from both populations have not been compared so far, neither from cross-sectional nor from longitudinal datasets. The present study aimed to compare features of cortical folding between healthy fetuses and early imaged preterm newborns on a cross-sectional basis, over a developmental period critical for the folding process (21-36 weeks of gestational age [GA]). A particular attention was carried out to reduce the methodological biases between the 2 populations. To provide an accurate group comparison, several global parameters characterizing the cortical morphometry were derived. In both groups, those metrics provided good proxies for the dramatic brain growth and cortical folding over this developmental period. Except for the cortical volume and the rate of sulci appearance, they depicted different trajectories in both groups suggesting that the transition from into ex utero has a visible impact on cortical morphology that is at least dependent on the GA at birth in preterm newborns.

Keywords : Cortical surface Curvature Development of cortical sulci Fetal MRI In utero Morphometry Premature birth Segmentation

Document type :

Journal articles

Domain :

Engineering Sciences [physics] / Signal and Image processing

Life Sciences [q-bio] / Bioengineering / Imaging

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https://hal.archives-ouvertes.fr/hal-01342582
Contributor : Bibliothèque Télécom Bretagne <>
Submitted on : Wednesday, July 6, 2016 - 1:34:00 PM
Last modification on : Wednesday, October 14, 2020 - 3:45:36 AM

Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns?

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Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns?

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