A slow-fast dynamic decomposition links neutral and non-neutral coexistence in interacting multi-strain pathogens

Abstract : Understanding the dynamics of multi-type microbial ecosystems remains a challenge, despite advancing molecular technologies for diversity resolution within and between hosts. Analytical progress becomes difficult when modelling realistic levels of community richness, relying on computationally-intensive simulations and detailed parametrisation. Simplification of dynamics in polymorphic pathogen systems is possible using aggregation methods and the slow-fast dynamics approach. Here we develop one new such framework, tailored to the epidemiology of an endemic multi-strain pathogen. We apply Goldstone’s idea of slow dynamics resulting from spontaneously broken symmetries, to study direct interactions in co-colonization, ranging from competition to facilitation between strains. The slow-fast dynamics approach interpolates between a neutral and non-neutral model for multi-strain coexistence, and quantifies the exact asymmetries that are important for the maintenance and stabilisation of diversity.
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https://hal.archives-ouvertes.fr/hal-01342432
Contributor : Sten Madec <>
Submitted on : Monday, July 11, 2016 - 11:31:54 AM
Last modification on : Friday, January 4, 2019 - 5:33:38 PM

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Erida Gjini, Sten Madec. A slow-fast dynamic decomposition links neutral and non-neutral coexistence in interacting multi-strain pathogens. 2016. ⟨hal-01342432⟩

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