Study of the Structure-Activity Relationship in a Heterogeneous Copper-Palladium Catalysed Suzuki-Miyaura Coupling
Résumé
Copper-palladium bimetallic catalyst supported on 4 molecular sieve prepared with two-step wet impregnation was successfully applied in the Suzuki-Miyaura reaction. The reaction took place with a variety of substituted boronic acids as well as with a collection of iodo- and bromobenzene derivatives. In some cases steric effects had influence on the reaction, ortho-substituted iodo- or bromobenzenes gave lower yield independently from the substituent. But most m- and p-substituted iodo- and bromobenzenes showed good to excellent activity. Several biphenyls were obtained by two or even three pathways: either the boronic acid or the respective iodo- or bromobenzene was functionalised.