pH-operated hybrid silica nanoparticles with multiple H-bond stoppers for colon cancer therapy

Christophe Théron (1) , Audrey Gallud (2) , Simon Giret (1) , Marie Maynadier (3) , Damien Grégoire (4) , Pierre Institut Chirurgie Visc¦rale, Clinique Mutualiste Beau-Soleil Puche (5) , Eric Jacquet (5) , Georges Pop (5) , Olivia Sgarbura (6) , Virginie Bellet (2) , Urszula Hibner (4) , Jeffrey I. I Zink (7) , Marcel Garcia (2) , Michel Wong Chi Man (1) , Carole Carcel (1) , Magali Gary-Bobo (2)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 NMS - NanoMedSyn
4 IGMM - Institut de Génétique Moléculaire de Montpellier
5 Clinique Beau Soleil [Montpellier]
6 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
7 UCLA - Department of Chemistry and Biochemistry

The transport of anticancer molecules by nanoparticles has shown great promise in terms of bioavailability, concentrating drugs in the tumor area and minimizing drug side effects. Here, we report the high efficiency of pH-operated hybrid silica nanocarriers for colon cancer therapy. These silica nanoparticles carry the drugs which are tightly held by cyanuric acid as a new type of stopper. The latter can be autonomously removed upon acidic medium allowing a direct drug release inside the cancer cells. Importantly, the proof of concept was established by ex vivo experiments using primary cell cultures from patient biopsies.

Domaines: Matériaux; Chimie

Christophe Théron, Audrey Gallud, Simon Giret, Marie Maynadier, Damien Grégoire, et al.. pH-operated hybrid silica nanoparticles with multiple H-bond stoppers for colon cancer therapy. RSC Advances, 2015, 5, pp.64932-64936. ⟨10.1039/c5ra09891b⟩. ⟨hal-01214697⟩