Defining the spectrum of frontotemporal dementias associated with TARDBP mutations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neurology Genetics Année : 2016

Defining the spectrum of frontotemporal dementias associated with TARDBP mutations

Philippe Couratier
  • Fonction : Auteur
  • PersonId : 889820
Tsz Hang Wong
  • Fonction : Auteur
Véronique Golfier
  • Fonction : Auteur
Sophie Auriacombe
  • Fonction : Auteur
Serge Belliard
  • Fonction : Auteur
Bernard Laurent
  • Fonction : Auteur
Serena Lattante
  • Fonction : Auteur
John C. van Swieten
  • Fonction : Auteur

Résumé

Objectives: We describe the largest series of patients with TARDBP mutations presenting with frontotemporal dementia (FTD) and review the cases in the literature to precisely characterize FTD diseases associated with this genotype. Methods: The phenotypic characteristics of 29 TARDBP patients, including 10 new French and Dutch cases and 19 reviewed from the literature, were evaluated. Results: The most frequent phenotype was a behavioral variant frontotemporal dementia (bvFTD), but a significant proportion (40%) of our patients had semantic (svFTD) or nonfluent variants (nfvFTD) at onset; and svFTD was significantly more frequent in TARDBP carriers than in other FTD genotypes (p < 0.001). Remarkably, only a minority (40%) of our patients secondarily developed amyotrophic lateral sclerosis (ALS). Two patients carried a homozygous mutation but strikingly different phenotypes (bvFTD and ALS) indicating that homozygosity does not result in a specific phenotype. Earlier age at onset in children than parent's generations, mimicking an apparent “anticipation” (21.8 ± 9.3 years, p = 0.001), and possible reduced penetrance were present in most families. Conclusions: This study enlarges the phenotypic spectrum of TARDBP and will have important clinical implications: (1) FTD can be the only clinical manifestation of TARDBP mutations; (2) Initial language or semantic disorders might be indicative of a specific genotype; (3) Mutations should be searched in all FTD phenotypes after exclusion of major genes, even in the absence of ALS in the proband or in family history; (4) reduced penetrance and clinical variability should be considered to deliver appropriate genetic counseling.

Domaines

Génétique

Dates et versions

hal-01332741 , version 1 (16-06-2016)

Identifiants

Citer

Paola Caroppo, Agnès Camuzat, Léna Guillot-Noel, Catherine Thomas-Antérion, Philippe Couratier, et al.. Defining the spectrum of frontotemporal dementias associated with TARDBP mutations . Neurology Genetics, 2016, 2 (3), pp. e80 ⟨10.1212/NXG.0000000000000080⟩. ⟨hal-01332741⟩
163 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More