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Statistical mechanics of the Huxley-Simmons model

Abstract : The chemomechanical model of Huxley and Simmons (HS) [A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971)] provides a paradigmatic description of mechanically induced collective conformational changes relevant in a variety of biological contexts, from muscles power-stroke and hair cell gating to integrin binding and hairpin unzipping. We develop a statistical mechanical perspective on the HS model by exploiting a formal analogy with a paramagnetic Ising model. We first study the equilibrium HS model with a finite number of elements and compute explicitly its mechanical and thermal properties. To model kinetics, we derive a master equation and solve it for several loading protocols. The developed formalism is applicable to a broad range of allosteric systems with mean-field interactions.
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Contributor : Matthieu Caruel <>
Submitted on : Thursday, May 26, 2016 - 4:22:21 PM
Last modification on : Sunday, June 20, 2021 - 3:34:18 AM
Long-term archiving on: : Saturday, August 27, 2016 - 10:43:48 AM


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M. Caruel, L. Truskinovsky. Statistical mechanics of the Huxley-Simmons model. Physical Review E , American Physical Society (APS), 2016, 93 (6), pp.062407. ⟨10.1103/PhysRevE.93.062407⟩. ⟨hal-01322113⟩



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