P. Acinetobacter-baumannii and . Aeruginosa-in-brooklyn, NY: the preantibiotic era has returned, Arch Intern Med, vol.162, pp.1515-1520, 2002.

M. Kollef, Inadequate Antimicrobial Treatment: An Important Determinant of Outcome for Hospitalized Patients, Clinical Infectious Diseases, vol.31, issue.Supplement 4, pp.131-138, 2000.
DOI : 10.1086/314079

M. Kollef, G. Sherman, S. Ward, and V. Fraser, Inadequate Antimicrobial Treatment of Infections, Chest, vol.115, issue.2, pp.462-474, 1999.
DOI : 10.1378/chest.115.2.462

A. Kumar, Early Antimicrobial Therapy in Severe Sepsis and Septic Shock, Current Infectious Disease Reports, vol.24, issue.5, pp.336-344, 2010.
DOI : 10.1007/s11908-010-0128-x

A. Kumar, D. Roberts, K. Wood, B. Light, J. Parrillo et al., Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*, Critical Care Medicine, vol.34, issue.6, pp.1589-1596, 2006.
DOI : 10.1097/01.CCM.0000217961.75225.E9

A. Kumar, R. Zarychanski, B. Light, J. Parrillo, D. Maki et al., Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*, Critical Care Medicine, vol.38, issue.9, pp.1773-1785, 2010.
DOI : 10.1097/CCM.0b013e3181eb3ccd

R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach et al., Surviving Sepsis Campaign, Critical Care Medicine, vol.41, issue.2, pp.2012580-637, 2013.
DOI : 10.1097/CCM.0b013e31827e83af

R. Masterton, A. Galloway, G. French, M. Street, J. Armstrong et al., Guidelines for the management of hospital-acquired pneumonia in the UK: Report of the Working Party on Hospital-Acquired Pneumonia of the British Society for Antimicrobial Chemotherapy, Journal of Antimicrobial Chemotherapy, vol.62, issue.1
DOI : 10.1093/jac/dkn162

J. Muscedere, P. Dodek, S. Keenan, R. Fowler, D. Cook et al., Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: Diagnosis and treatment, Journal of Critical Care, vol.23, issue.1, pp.138-147, 2008.
DOI : 10.1016/j.jcrc.2007.12.008

A. Amaral and M. Holder, Timing of Antimicrobial Therapy after Identification of Ventilator-Associated Condition Is Not Associated with Mortality in Patients with Ventilator-Associated Pneumonia: A Cohort Study, PLoS ONE, vol.165, issue.5, p.97575, 2014.
DOI : 10.1371/journal.pone.0097575.t002

F. Bloos, D. Thomas-ruddel, H. Ruddel, C. Engel, D. Schwarzkopf et al., Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study, Critical Care, vol.18, issue.2, p.42, 2014.
DOI : 10.1007/s00134-012-2695-9

T. Hranjec, L. Rosenberger, B. Swenson, R. Metzger, T. Flohr et al., Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study, The Lancet Infectious Diseases, vol.12, issue.10, pp.774-780, 2012.
DOI : 10.1016/S1473-3099(12)70151-2

J. Pines, J. Isserman, and P. Hinfey, The Measurement of Time to First Antibiotic Dose for Pneumonia in the Emergency Department: A White Paper and Position Statement Prepared for the American Academy of Emergency Medicine, The Journal of Emergency Medicine, vol.37, issue.3, pp.335-340, 2009.
DOI : 10.1016/j.jemermed.2009.06.127

E. Quattromani, E. Powell, R. Khare, N. Cheema, K. Sauser et al., Hospital-reported Data on the Pneumonia Quality Measure ???Time to First Antibiotic Dose??? Are Not Associated With Inpatient Mortality: Results of a Nationwide Cross-sectional Analysis, Academic Emergency Medicine, vol.336, issue.5, pp.496-503, 2011.
DOI : 10.1111/j.1553-2712.2011.01053.x

J. Welker, M. Huston, and J. Mccue, Antibiotic Timing and Errors in Diagnosing Pneumonia, Archives of Internal Medicine, vol.168, issue.4, pp.351-356, 2008.
DOI : 10.1001/archinternmed.2007.84

D. Yahav, L. Leibovici, E. Goldberg, J. Bishara, and M. Paul, Time to first antibiotic dose for patients hospitalised with community-acquired pneumonia, International Journal of Antimicrobial Agents, vol.41, issue.5
DOI : 10.1016/j.ijantimicag.2013.01.008

L. Bouadma, C. Luyt, F. Tubach, C. Cracco, A. Alvarez et al., Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial, The Lancet, vol.375, issue.9713, pp.463-474, 2010.
DOI : 10.1016/S0140-6736(09)61879-1

N. Layios, B. Lambermont, J. Canivet, P. Morimont, J. Preiser et al., Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients*, Critical Care Medicine, vol.40, issue.8, pp.2304-2309, 2012.
DOI : 10.1097/CCM.0b013e318251517a

C. Luyt, A. Combes, J. Trouillet, and J. Chastre, Value of the Serum Procalcitonin Level to Guide Antimicrobial Therapy for Patients with Ventilator-Associated Pneumonia, Seminars in Respiratory and Critical Care Medicine, vol.32, issue.02, pp.181-187, 2011.
DOI : 10.1055/s-0031-1275530

P. Schuetz, W. Albrich, M. Christ-crain, J. Chastre, and B. Mueller, Procalcitonin for guidance of antibiotic therapy, Expert Review of Anti-infective Therapy, vol.8, issue.5, pp.575-587, 2010.
DOI : 10.1586/eri.10.25

P. Schuetz, B. Muller, M. Christ-crain, D. Stolz, M. Tamm et al., Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections, Cochrane Database Syst Rev, vol.2012, issue.9, p.7498

B. Uzzan, R. Cohen, P. Nicolas, M. Cucherat, and G. Perret, Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis, Critical Care Medicine, vol.34, issue.7, pp.1996-2003, 2006.
DOI : 10.1097/01.CCM.0000226413.54364.36

C. Wacker, A. Prkno, F. Brunkhorst, and P. Schlattmann, Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis, The Lancet Infectious Diseases, vol.13, issue.5, pp.426-435, 2013.
DOI : 10.1016/S1473-3099(12)70323-7

J. Quenot, C. Luyt, N. Roche, M. Chalumeau, P. Charles et al., Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy, Annals of Intensive Care, vol.3, issue.1, p.21, 2013.
DOI : 10.1128/AAC.00335-11
URL : https://hal.archives-ouvertes.fr/inserm-00845823

J. Jensen, L. Hein, B. Lundgren, M. Bestle, T. Mohr et al., Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial*, Critical Care Medicine, vol.39, issue.9, pp.2048-2058, 2011.
DOI : 10.1097/CCM.0b013e31821e8791

R. Pfister, M. Kochanek, T. Leygeber, C. Brun-buisson, E. Cuquemelle et al., Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis, Critical Care, vol.18, issue.2, p.44, 2014.
DOI : 10.1136/thx.2010.151522

D. Annane, V. Maxime, J. Faller, C. Mezher, C. Clec-'h et al., Procalcitonin levels to guide antibiotic therapy in adults with non-microbiologically proven apparent severe sepsis: a randomised controlled trial, BMJ Open, vol.3, issue.2, p.2186, 2013.
DOI : 10.1136/bmjopen-2012-002186

J. Chastre and J. Fagon, Ventilator-associated Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.165, issue.7, pp.867-903, 2002.
DOI : 10.1164/ajrccm.165.7.2105078

J. Trouillet, A. Vuagnat, A. Combes, N. Kassis, J. Chastre et al., Ventilator???Associated Pneumonia: Comparison of Episodes Due to Piperacillin???Resistant versus Piperacillin???Susceptible Organisms, Clinical Infectious Diseases, vol.34, issue.8, pp.1047-1054, 2002.
DOI : 10.1086/339488

Y. Carmeli, N. Troillet, G. Eliopoulos, and M. Samore, Emergence of antibioticresistant pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents, Antimicrob Agents Chemother, vol.43, pp.1379-1382, 1999.

C. Luyt, A. A. Lu, Q. Micaelo, M. Brechot, N. Brossier et al., Imipenem, Meropenem, or Doripenem To Treat Patients with Pseudomonas aeruginosa Ventilator-Associated Pneumonia, Antimicrobial Agents and Chemotherapy, vol.58, issue.3, pp.1372-1380, 2014.
DOI : 10.1128/AAC.02109-13

N. Brusselaers, S. Labeau, D. Vogelaers, and S. Blot, Value of lower respiratory tract surveillance cultures to predict bacterial pathogens in ventilator-associated pneumonia: systematic review and diagnostic test accuracy meta-analysis, Intensive Care Medicine, vol.16, issue.Suppl 2, pp.365-375, 2013.
DOI : 10.1007/s00134-012-2759-x

F. Michel, B. Franceschini, P. Berger, J. Arnal, M. Gainnier et al., Early Antibiotic Treatment for BAL-Confirmed Ventilator-Associated Pneumonia, Chest, vol.127, issue.2, pp.589-597, 2005.
DOI : 10.1378/chest.127.2.589

J. Martinez, N. Cobos-trigueros, A. Soriano, M. Almela, M. Ortega et al., Influence of Empiric Therapy with a ??-Lactam Alone or Combined with an Aminoglycoside on Prognosis of Bacteremia Due to Gram-Negative Microorganisms, Antimicrobial Agents and Chemotherapy, vol.54, issue.9, pp.3590-3596, 2010.
DOI : 10.1128/AAC.00115-10

S. Micek, E. Welch, J. Khan, M. Pervez, J. Doherty et al., Empiric Combination Antibiotic Therapy Is Associated with Improved Outcome against Sepsis Due to Gram-Negative Bacteria: a Retrospective Analysis, Antimicrobial Agents and Chemotherapy, vol.54, issue.5, pp.1742-1748, 2010.
DOI : 10.1128/AAC.01365-09

J. Chalmers, J. Taylor, A. Singanayagam, G. Fleming, A. Akram et al., Epidemiology, Antibiotic Therapy, and Clinical Outcomes in Health Care-Associated Pneumonia: A UK Cohort Study, Clinical Infectious Diseases, vol.53, issue.2, pp.107-113, 2011.
DOI : 10.1093/cid/cir274

C. Garcia-vidal, D. Viasus, A. Roset, J. Adamuz, R. Verdaguer et al., Low incidence of multidrug-resistant organisms in patients with healthcare-associated pneumonia requiring hospitalization, Clinical Microbiology and Infection, vol.17, issue.11, pp.1659-1665, 2011.
DOI : 10.1111/j.1469-0691.2011.03484.x

S. Aliberti, D. Pasquale, M. Zanaboni, A. Cosentini, R. Brambilla et al., Stratifying Risk Factors for Multidrug-Resistant Pathogens in Hospitalized Patients Coming From the Community With Pneumonia, Clinical Infectious Diseases, vol.54, issue.4, pp.470-478, 2012.
DOI : 10.1093/cid/cir840

T. Cardoso, O. Ribeiro, I. Aragao, A. Costa-pereira, and A. Sarmento, Additional risk factors for infection by multidrug-resistant pathogens in healthcare-associated infection: a large cohort study, BMC Infectious Diseases, vol.40, issue.5, p.375, 2012.
DOI : 10.1086/430314

B. Jeong, W. Koh, H. Yoo, S. Um, G. Suh et al., Performances of Prognostic Scoring Systems in Patients With Healthcare-Associated Pneumonia, Clinical Infectious Diseases, vol.56, issue.5, pp.625-632, 2013.
DOI : 10.1093/cid/cis970

Y. Shindo, R. Ito, D. Kobayashi, M. Ando, M. Ichikawa et al., Risk Factors for Drug-Resistant Pathogens in Community-acquired and Healthcare-associated Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.188, issue.8, pp.985-995, 2013.
DOI : 10.1164/rccm.201301-0079OC

J. Chalmers, C. Rother, W. Salih, and S. Ewig, Healthcare-Associated Pneumonia Does Not Accurately Identify Potentially Resistant Pathogens: A Systematic Review and Meta-Analysis, Clinical Infectious Diseases, vol.58, issue.3, pp.330-339, 2014.
DOI : 10.1093/cid/cit734

S. Park, E. Kim, Y. Kang, M. Park, Y. Kim et al., Validation of a scoring tool to predict drug-resistant pathogens in hospitalised pneumonia patients, The International Journal of Tuberculosis and Lung Disease, vol.17, issue.5, pp.704-709, 2013.
DOI : 10.5588/ijtld.12.0723

A. Shorr, M. Zilberberg, R. Reichley, J. Kan, A. Hoban et al., Validation of a Clinical Score for Assessing the Risk of Resistant Pathogens in Patients With Pneumonia Presenting to the Emergency Department, Clinical Infectious Diseases, vol.54, issue.2, pp.193-198, 2012.
DOI : 10.1093/cid/cir813

A. Clark, E. Kaleta, A. Arora, and D. Wolk, Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry: a Fundamental Shift in the Routine Practice of Clinical Microbiology, Clinical Microbiology Reviews, vol.26, issue.3, pp.547-603, 2013.
DOI : 10.1128/CMR.00072-12

J. Hrabak, E. Chudackova, and R. Walkova, Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) Mass Spectrometry for Detection of Antibiotic Resistance Mechanisms: from Research to Routine Diagnosis, Clinical Microbiology Reviews, vol.26, issue.1, pp.103-114, 2013.
DOI : 10.1128/CMR.00058-12

O. Clerc, G. Prod-'hom, C. Vogne, A. Bizzini, T. Calandra et al., Impact of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry on the Clinical Management of Patients With Gram-negative Bacteremia: A Prospective Observational Study, Clinical Infectious Diseases, vol.56, issue.8, pp.1101-1107, 2013.
DOI : 10.1093/cid/cis1204

E. Bouza, M. Torres, C. Radice, E. Cercenado, R. De-diego et al., Direct E-Test (AB Biodisk) of Respiratory Samples Improves Antimicrobial Use in Ventilator-Associated Pneumonia, Clinical Infectious Diseases, vol.44, issue.3, pp.382-387, 2007.
DOI : 10.1086/510587

H. Arnold, J. Hollands, L. Skrupky, J. Smith, P. Juang et al., Prolonged Infusion Antibiotics for Suspected Gram-Negative Infections in the ICU: A Before-After Study, Annals of Pharmacotherapy, vol.66, issue.2, pp.170-180, 2013.
DOI : 10.1097/01.CCM.0000217961.75225.E9

J. Dulhunty, J. Roberts, J. Davis, S. Webb, R. Bellomo et al., Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial, Clinical Infectious Diseases, vol.56, issue.2, pp.236-244, 2013.
DOI : 10.1093/cid/cis856

J. Shiu, E. Wang, A. Tejani, and M. Wasdell, Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections, Cochrane Database Syst Rev, vol.46, issue.4, p.8481, 2013.
DOI : 10.1002/14651858.CD008481.pub2

M. Walker, W. Lam, and K. Manasco, Continuous and Extended Infusions of ??-Lactam Antibiotics in the Pediatric Population, Annals of Pharmacotherapy, vol.14, issue.11, pp.1537-1546, 2012.
DOI : 10.1097/MCC.0b013e3282e2a98f

M. Falagas, G. Tansarli, K. Ikawa, and K. Vardakas, Clinical Outcomes With Extended or Continuous Versus Short-term Intravenous Infusion of Carbapenems and Piperacillin/Tazobactam: A Systematic Review and Meta-analysis, Clinical Infectious Diseases, vol.56, issue.2, pp.272-282, 2013.
DOI : 10.1093/cid/cis857

M. Abdul-aziz, J. Dulhunty, R. Bellomo, . J. Lipman, and J. Roberts, Continuous beta-lactam infusion in critically ill patients: the clinical evidence, Annals of Intensive Care, vol.2, issue.1, p.37
DOI : 10.1086/514622

J. Roberts, M. Aziz, . J. Lipman, J. Mouton, A. Vinks et al., Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions, The Lancet Infectious Diseases, vol.14, issue.6, pp.498-509, 2014.
DOI : 10.1016/S1473-3099(14)70036-2

F. Baquero, E. Culebras, C. Patron, J. Perez-diaz, J. Medrano et al., Postantibiotic effect of imipenem on Gram-positive and Gram-negative micro-organisms, Journal of Antimicrobial Chemotherapy, vol.18, issue.Supplement_E, pp.47-59, 1986.
DOI : 10.1093/jac/18.Supplement_E.47

J. Spivey, The postantibiotic effect, Clin Pharm, vol.11, pp.865-875, 1992.

F. Taccone, P. Laterre, T. Dugernier, H. Spapen, I. Delattre et al., Insufficient ??-lactam concentrations in the early phase of severe sepsis and septic shock, Critical Care, vol.14, issue.4, p.126, 2010.
DOI : 10.1186/cc9091

W. Duszynska, F. Taccone, M. Hurkacz, B. Kowalska-krochmal, A. Wiela-hojenska et al., Therapeutic drug monitoring of amikacin in septic patients, Critical Care, vol.17, issue.4, p.165, 2013.
DOI : 10.1086/520991

F. Pea, P. Viale, F. Pavan, and M. Furlanut, Pharmacokinetic Considerations for Antimicrobial Therapy in Patients Receiving Renal Replacement Therapy, Clinical Pharmacokinetics, vol.41, issue.12, pp.997-1038, 2007.
DOI : 10.2165/00003088-200746120-00003

D. Roberts, J. Roberts, M. Roberts, X. Liu, P. Nair et al., Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy, Critical Care Medicine, vol.40, issue.5, pp.1523-1528, 2012.
DOI : 10.1097/CCM.0b013e318241e553

R. Trotman, J. Williamson, D. Shoemaker, and W. Salzer, Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy, Clinical Infectious Diseases, vol.41, issue.8, pp.1159-1166, 2005.
DOI : 10.1086/444500

T. Lodise and G. Drusano, Pharmacokinetics and Pharmacodynamics: Optimal Antimicrobial Therapy in the Intensive Care Unit, Critical Care Clinics, vol.27, issue.1, pp.1-18, 2011.
DOI : 10.1016/j.ccc.2010.11.003

F. Taccone, P. Laterre, H. Spapen, T. Dugernier, I. Delattre et al., Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock, Critical Care, vol.14, issue.2, p.53, 2010.
DOI : 10.1186/cc8945

J. Teo, Y. Liew, W. Lee, and A. Kwa, Prolonged infusion versus intermittent boluses of ??-lactam antibiotics for treatment of acute infections: a meta-analysis, International Journal of Antimicrobial Agents, vol.43, issue.5, pp.403-411, 2014.
DOI : 10.1016/j.ijantimicag.2014.01.027

I. Delattre, F. Musuamba, P. Jacqmin, F. Taccone, P. Laterre et al., Population pharmacokinetics of four ??-lactams in critically ill septic patients comedicated with amikacin, Clinical Biochemistry, vol.45, issue.10-11, pp.780-786, 2012.
DOI : 10.1016/j.clinbiochem.2012.03.030

M. Grill and R. Maganti, Neurotoxic effects associated with antibiotic use: management considerations, British Journal of Clinical Pharmacology, vol.51, issue.3, pp.381-393, 2011.
DOI : 10.1111/j.1365-2125.2011.03991.x

G. Naeije, S. Lorent, J. Vincent, and B. Legros, Continuous Epileptiform Discharges in Patients Treated With Cefepime or Meropenem, Archives of Neurology, vol.68, issue.10, pp.1303-1307, 2011.
DOI : 10.1001/archneurol.2011.204

M. Kollef, J. Chastre, M. Clavel, M. Restrepo, B. Michiels et al., A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia, Critical Care, vol.16, issue.6, p.218, 2012.
DOI : 10.1164/rccm.201102-0349OC

A. Udy, J. Baptista, N. Lim, G. Joynt, P. Jarrett et al., Augmented Renal Clearance in the ICU, Critical Care Medicine, vol.42, issue.3, pp.520-527, 2014.
DOI : 10.1097/CCM.0000000000000029

C. Luyt, A. Jacob, A. Combes, A. Nieszkowszka, C. Fernandez et al., Nktr-061 (inhaled amikacin) achieves high epithelial lining fluid concentrations in gram-negative pneumonia in intubated and mechanically ventilated patients [abstract], Am J Respir Crit Care Med, vol.175, p.328, 2007.

M. Niederman, J. Chastre, K. Corkery, J. Fink, C. Luyt et al., BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia, Intensive Care Medicine, vol.13, issue.Suppl 1, pp.263-271, 2012.
DOI : 10.1007/s00134-011-2420-0

L. Palmer, G. Smaldone, J. Chen, D. Baram, T. Duan et al., Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit*, Critical Care Medicine, vol.36, issue.7, pp.2008-2013, 2008.
DOI : 10.1097/CCM.0b013e31817c0f9e

C. Luyt, A. Combes, A. Nieszkowska, J. Trouillet, and J. Chastre, Aerosolized antibiotics to treat ventilator-associated pneumonia, Current Opinion in Infectious Diseases, vol.22, issue.2, pp.154-158, 2009.
DOI : 10.1097/QCO.0b013e328322a006

C. Luyt, M. Eldon, H. Stass, D. Gribben, K. Corkery et al., Pharmacokinetics and Tolerability of Amikacin Administered as BAY41-6551 Aerosol in Mechanically Ventilated Patients with Gram-Negative Pneumonia and Acute Renal Failure, Journal of Aerosol Medicine and Pulmonary Drug Delivery, vol.24, issue.4, pp.183-190, 2011.
DOI : 10.1089/jamp.2010.0860

L. Palmer and G. Smaldone, Reduction of Bacterial Resistance with Inhaled Antibiotics in the Intensive Care Unit, American Journal of Respiratory and Critical Care Medicine, vol.189, issue.10, pp.1225-1233, 2014.
DOI : 10.1164/rccm.201312-2161OC

R. Stevens, D. Teres, J. Skillman, and D. Feingold, Pneumonia in an intensive care unit. A 30-month experience, Archives of Internal Medicine, vol.134, issue.1, pp.106-111, 1974.
DOI : 10.1001/archinte.134.1.106

E. Buelow, T. Gonzalez, D. Versluis, E. Oostdijk, L. Ogilvie et al., Schaik W: Effects of selective digestive decontamination (SDD) on the gut resistome, J Antimicrob Chemother, 2014.

E. Oostdijk, L. Smits, A. De-smet, M. Leverstein-van-hall, J. Kesecioglu et al., Colistin resistance in gram-negative bacteria during prophylactic topical colistin use in intensive care units, Intensive Care Medicine, vol.33, issue.Suppl 1, pp.653-660, 2013.
DOI : 10.1007/s00134-012-2761-3

N. Singh, P. Rogers, C. Atwood, M. Wagener, and V. Yu, Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription

A. Torres and S. Ewig, Diagnosing Ventilator-Associated Pneumonia, New England Journal of Medicine, vol.350, issue.5, pp.433-435, 2004.
DOI : 10.1056/NEJMp038219

V. Baselski and R. Wunderink, Bronchoscopic diagnosis of pneumonia., Clinical Microbiology Reviews, vol.7, issue.4, pp.533-558, 1994.
DOI : 10.1128/CMR.7.4.533

J. Fagon, J. Chastre, M. Wolff, C. Gervais, S. Parer-aubas et al., Invasive and Noninvasive Strategies for Management of Suspected Ventilator-Associated Pneumonia, Annals of Internal Medicine, vol.132, issue.8, pp.621-630, 2000.
DOI : 10.7326/0003-4819-132-8-200004180-00004

P. Charbonneau, J. Parienti, P. Thibon, M. Ramakers, C. Daubin et al., Fluoroquinolone Use and Methicillin-Resistant Staphylococcus aureus Isolation Rates in Hospitalized Patients: A Quasi Experimental Study, Clinical Infectious Diseases, vol.42, issue.6, pp.778-784, 2006.
DOI : 10.1086/500319

S. Nseir, D. Pompeo, C. Soubrier, S. Delour, P. Lenci et al., First-generation fluoroquinolone use and subsequent emergence of multiple drug-resistant bacteria in the intensive care unit*, Critical Care Medicine, vol.33, issue.2, pp.283-289, 2005.
DOI : 10.1097/01.CCM.0000152230.53473.A1

O. Cornely, M. Bassetti, C. T. Garbino, J. Kullberg, B. Lortholary et al., ESCMID* *This guideline was presented in part at ECCMID 2011. European Society for Clinical Microbiology and Infectious Diseases. guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients, Clinical Microbiology and Infection, vol.18, pp.19-37, 2012.
DOI : 10.1111/1469-0691.12039

J. Rello, L. Vidaur, A. Sandiumenge, A. Rodriguez, B. Gualis et al., De-escalation therapy in ventilator-associated pneumonia*, Critical Care Medicine, vol.32, issue.11, pp.2183-2190, 2004.
DOI : 10.1097/01.CCM.0000145997.10438.28

E. Giantsou, N. Liratzopoulos, E. Efraimidou, M. Panopoulou, E. Alepopoulou et al., De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate, Intensive Care Medicine, vol.122, issue.6, pp.1533-1540, 2007.
DOI : 10.1007/s00134-007-0619-x

R. Kaki, M. Elligsen, S. Walker, A. Simor, L. Palmay et al., Impact of antimicrobial stewardship in critical care: a systematic review, Journal of Antimicrobial Chemotherapy, vol.66, issue.6, pp.1223-1230, 2011.
DOI : 10.1093/jac/dkr137

J. Kim, J. Chung, S. Choi, H. Jang, S. Hong et al., Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial, Critical Care, vol.16, issue.1, p.28, 2012.
DOI : 10.1016/j.ijheh.2008.07.001

B. Silva, R. Andriolo, A. Atallah, and R. Salomao, De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock, Cochrane Database Syst Rev, vol.12, issue.6, p.7934, 2013.
DOI : 10.1002/14651858.CD007934.pub3

I. Bliziotis, G. Samonis, K. Vardakas, S. Chrysanthopoulou, and M. Falagas, Effect of Aminoglycoside and ?????Lactam Combination Therapy versus ?????Lactam Monotherapy on the Emergence of Antimicrobial Resistance: A Meta???analysis of Randomized, Controlled Trials, Clinical Infectious Diseases, vol.41, issue.2, pp.149-158, 2005.
DOI : 10.1086/430912

F. Brunkhorst, M. Oppert, G. Marx, F. Bloos, K. Ludewig et al., Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis, JAMA, vol.307, issue.22, pp.2390-2399, 2012.
DOI : 10.1001/jama.2012.5833

E. Chamot, B. El-amari, E. Rohner, P. Van-delden, and C. , Effectiveness of Combination Antimicrobial Therapy for Pseudomonas aeruginosa Bacteremia, Antimicrobial Agents and Chemotherapy, vol.47, issue.9, pp.2756-2764, 2003.
DOI : 10.1128/AAC.47.9.2756-2764.2003

A. Cometta, T. Calandra, H. Gaya, S. Zinner, R. De-bock et al., Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto Infection Program, Antimicrob Agents Chemother, vol.40, pp.1108-1115, 1996.

H. Dupont, C. Carbon, and J. Carlet, Monotherapy with a Broad-Spectrum Beta-Lactam Is as Effective as Its Combination with an Aminoglycoside in Treatment of Severe Generalized Peritonitis: a Multicenter Randomized Controlled Trial, Antimicrobial Agents and Chemotherapy, vol.44, issue.8, pp.2028-2033, 2000.
DOI : 10.1128/AAC.44.8.2028-2033.2000

M. Falagas, D. Matthaiou, and I. Bliziotis, The role of aminoglycosides in combination with a ??-lactam for the treatment of bacterial endocarditis: a meta-analysis of comparative trials, Journal of Antimicrobial Chemotherapy, vol.57, issue.4, pp.639-647, 2006.
DOI : 10.1093/jac/dkl044

P. Furno, G. Bucaneve, D. Favero, and A. , Monotherapy or aminoglycoside-containing combinations for empirical antibiotic treatment of febrile neutropenic patients: a meta-analysis, The Lancet Infectious Diseases, vol.2, issue.4, pp.231-242, 2002.
DOI : 10.1016/S1473-3099(02)00241-4

D. Heyland, P. Dodek, J. Muscedere, A. Day, and D. Cook, Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia*, Critical Care Medicine, vol.36, issue.3, pp.737-744, 2008.
DOI : 10.1097/01.CCM.0B013E31816203D6

A. Kumar, N. Safdar, S. Kethireddy, and D. Chateau, A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: A meta-analytic/meta-regression study, Critical Care Medicine, vol.38, issue.8, pp.1651-1664, 2010.
DOI : 10.1097/CCM.0b013e3181e96b91

M. Paul, I. Silbiger, S. Grozinsky, K. Soares-weiser, and L. Leibovici, Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis, Cochrane Database Syst Rev, vol.1, p.3344, 2006.

P. Tamma, S. Cosgrove, and L. Maragakis, Combination Therapy for Treatment of Infections with Gram-Negative Bacteria, Clinical Microbiology Reviews, vol.25, issue.3, pp.450-470, 2012.
DOI : 10.1128/CMR.05041-11

R. Marcus, M. Paul, H. Elphick, and L. Leibovici, Clinical implications of ??-lactam???aminoglycoside synergism: systematic review of randomised trials, International Journal of Antimicrobial Agents, vol.37, issue.6, pp.491-503, 2011.
DOI : 10.1016/j.ijantimicag.2010.11.029

C. Pena, C. Suarez, A. Ocampo-sosa, J. Murillas, B. Almirante et al., Effect of Adequate Single-Drug vs Combination Antimicrobial Therapy on Mortality in Pseudomonas aeruginosa Bloodstream Infections: A Post Hoc Analysis of a Prospective Cohort, Clinical Infectious Diseases, vol.57, issue.2, pp.208-216, 2013.
DOI : 10.1093/cid/cit223

M. Woodhead, F. Blasi, S. Ewig, G. Huchon, M. Leven et al., Guidelines for the management of adult lower respiratory tract infections, European Respiratory Journal, vol.26, issue.6, pp.1138-1180, 2005.
DOI : 10.1183/09031936.05.00055705

J. Solomkin, J. Mazuski, J. Bradley, K. Rodvold, E. Goldstein et al., Diagnosis and Management of Complicated Intra???abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.50, issue.2, pp.133-164, 2010.
DOI : 10.1086/649554

A. Combes, C. Luyt, J. Fagon, M. Wolff, and J. Trouillet, Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia, Critical Care Medicine, vol.35, issue.1, pp.146-154, 2007.
DOI : 10.1097/01.CCM.0000249826.81273.E4

P. Dennesen, A. Van-der-ven, A. Kessels, G. Ramsay, and M. Bonten, Resolution of Infectious Parameters after Antimicrobial Therapy in Patients with Ventilator-associated Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.163, issue.6, pp.1371-1375, 2001.
DOI : 10.1164/ajrccm.163.6.2007020

C. Luna, D. Blanzaco, M. Niederman, W. Matarucco, N. Baredes et al., Resolution of ventilator-associated pneumonia: Prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome*, Critical Care Medicine, vol.31, issue.3, pp.676-682, 2003.
DOI : 10.1097/01.CCM.0000055380.86458.1E

J. Chastre, M. Wolff, J. Fagon, S. Chevret, F. Thomas et al., Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults, JAMA, vol.290, issue.19, pp.2588-2598, 2003.
DOI : 10.1001/jama.290.19.2588

S. Micek, S. Ward, V. Fraser, and M. Kollef, A Randomized Controlled Trial of an Antibiotic Discontinuation Policy for Clinically Suspected Ventilator-Associated Pneumonia, Chest, vol.125, issue.5, pp.1791-1799, 2004.
DOI : 10.1378/chest.125.5.1791

T. Hedrick, S. Mcelearney, R. Smith, H. Evans, T. Pruett et al., Duration of Antibiotic Therapy for Ventilator-Associated Pneumonia Caused by Non-Fermentative Gram-Negative Bacilli, Surgical Infections, vol.8, issue.6, pp.589-598, 2007.
DOI : 10.1089/sur.2006.021

G. Capellier, H. Mockly, C. Charpentier, D. Annane, G. Blasco et al., Early-Onset Ventilator-Associated Pneumonia in Adults Randomized Clinical Trial: Comparison of 8 versus 15 Days of Antibiotic Treatment, PLoS ONE, vol.7, issue.8, p.41290, 2012.
DOI : 10.1371/journal.pone.0041290.s002
URL : https://hal.archives-ouvertes.fr/hal-00825706

G. Dimopoulos, G. Poulakou, I. Pneumatikos, A. Armaganidis, M. Kollef et al., Short- vs Long-Duration Antibiotic Regimens for Ventilator-Associated Pneumonia, Chest, vol.144, issue.6, pp.1759-1767, 2013.
DOI : 10.1378/chest.13-0076

R. Pugh, C. Grant, R. Cooke, and G. Dempsey, Short-course versus prolongedcourse antibiotic therapy for hospital-acquired pneumonia in critically ill adults, Cochrane Database Syst Rev, vol.10, p.7577, 2011.

N. Eliakim-raz, D. Yahav, M. Paul, and L. Leibovici, Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection-- 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials, Journal of Antimicrobial Chemotherapy, vol.68, pp.2183-2191, 2013.
DOI : 10.1093/jac/dkt177

T. Havey, R. Fowler, and N. Daneman, Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis, Critical Care, vol.15, issue.6, p.267, 2011.
DOI : 10.1001/jama.283.12.1583

K. Kyriakidou, P. Rafailidis, D. Matthaiou, S. Athanasiou, and M. Falagas, Short- versus long-course antibiotic therapy for acute pyelonephritis in adolescents and adults: A meta-analysis of randomized controlled trials, Clinical Therapeutics, vol.30, issue.10, pp.1859-1868, 2008.
DOI : 10.1016/j.clinthera.2008.10.007

V. Nobre, S. Harbarth, J. Graf, P. Rohner, and J. Pugin, Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients, American Journal of Respiratory and Critical Care Medicine, vol.177, issue.5, pp.498-505, 2008.
DOI : 10.1164/rccm.200708-1238OC

P. Schuetz, M. Briel, M. Christ-crain, D. Stolz, L. Bouadma et al., Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis, Clinical Infectious Diseases, vol.55, issue.5, pp.651-662, 2012.
DOI : 10.1093/cid/cis464

P. Kopterides, I. Siempos, I. Tsangaris, A. Tsantes, and A. Armaganidis, Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: A systematic review and meta-analysis of randomized controlled trials, Critical Care Medicine, vol.38, issue.11, pp.2229-2241, 2010.
DOI : 10.1097/CCM.0b013e3181f17bf9

D. Matthaiou, G. Ntani, M. Kontogiorgi, G. Poulakou, A. Armaganidis et al., An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients, Intensive Care Medicine, vol.52, issue.6, pp.940-949, 2012.
DOI : 10.1007/s00134-012-2563-7

A. Prkno, C. Wacker, F. Brunkhorst, and P. Schlattmann, Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock ??? a systematic review and meta-analysis, Critical Care, vol.17, issue.6, p.291, 2013.
DOI : 10.1086/605630

M. Cotta, J. Roberts, A. Tabah, . J. Lipman, D. Vogelaers et al., Antimicrobial stewardship of ??-lactams in intensive care units, Expert Review of Anti-infective Therapy, vol.12, issue.5, pp.581-595, 2014.
DOI : 10.1586/14787210.2014.902308

T. Dellit, R. Owens, J. Mcgowan, . Jr, D. Gerding et al., Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship, Clinical Infectious Diseases, vol.44, issue.2, pp.159-177, 2007.
DOI : 10.1086/510393

K. Lawrence and M. Kollef, Antimicrobial Stewardship in the Intensive Care Unit, American Journal of Respiratory and Critical Care Medicine, vol.179, issue.6, pp.434-438, 2009.
DOI : 10.1164/rccm.200809-1394CP

P. Davey, E. Brown, L. Fenelon, R. Finch, I. Gould et al., Interventions to improve antibiotic prescribing practices for hospital inpatients, Cochrane Database Syst Rev, vol.4, p.3543, 2005.

G. Silva, B. Andriolo, R. Atallah, A. Salomao, and R. , De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock, Cochrane Database Syst Rev, vol.12, issue.6, p.7934, 2010.
DOI : 10.1002/14651858.CD007934.pub3

C. Weiss, D. Dibardino, J. Rho, N. Sung, B. Collander et al., A Clinical Trial Comparing Physician Prompting With an Unprompted Automated Electronic Checklist to Reduce Empirical Antibiotic Utilization, Critical Care Medicine, vol.41, issue.11, pp.2563-2569, 2013.
DOI : 10.1097/CCM.0b013e318298291a

C. Weiss, F. Moazed, C. Mcevoy, B. Singer, I. Szleifer et al., Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes, American Journal of Respiratory and Critical Care Medicine, vol.184, issue.6, pp.680-686, 2011.
DOI : 10.1164/rccm.201101-0037OC

S. Pestotnik, D. Classen, R. Evans, and J. Burke, Implementing Antibiotic Practice Guidelines through Computer-Assisted Decision Support: Clinical and Financial Outcomes, Annals of Internal Medicine, vol.124, issue.10, pp.884-890, 1996.
DOI : 10.7326/0003-4819-124-10-199605150-00004

D. Belletti, C. Zacker, and C. Mullins, Perspectives on electronic medical records adoption: electronic medical records (EMR) in outcomes research, Patient Related Outcome Measures, vol.1, pp.29-37, 2010.
DOI : 10.2147/PROM.S8896

R. Kullar, D. Goff, L. Schulz, B. Fox, and W. Rose, The "Epic" Challenge of Optimizing Antimicrobial Stewardship: The Role of Electronic Medical Records and Technology, Clinical Infectious Diseases, vol.57, issue.7, pp.1005-1013, 2013.
DOI : 10.1093/cid/cit318

L. Leibovici, V. Gitelman, Y. Yehezkelli, O. Poznanski, G. Milo et al., Improving empirical antibiotic treatment: prospective, nonintervention testing of a decision support system, Journal of Internal Medicine, vol.242, issue.5, pp.395-400, 1997.
DOI : 10.1046/j.1365-2796.1997.00232.x

T. Bailey, D. Ritchie, S. Mcmullin, M. Kahn, R. Reichley et al., A randomized, prospective evaluation of an interventional program to discontinue intravenous antibiotics at two tertiary care teaching institutions, Pharmacotherapy, vol.17, pp.277-281, 1997.

E. Ibrahim, S. Ward, G. Sherman, R. Schaiff, V. Fraser et al., Experience with a clinical guideline for the treatment of ventilator-associated pneumonia, Critical Care Medicine, vol.29, issue.6, pp.1109-1115, 2001.
DOI : 10.1097/00003246-200106000-00003

R. Rimawi, M. Mazer, D. Siraj, M. Gooch, and P. Cook, Impact of Regular Collaboration Between Infectious Diseases and Critical Care Practitioners on Antimicrobial Utilization and Patient Outcome*, Critical Care Medicine, vol.41, issue.9, pp.2099-2107, 2013.
DOI : 10.1097/CCM.0b013e31828e9863