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Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time

Abstract : AbstractOvine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrPSc phenotypes were present: G338 or Apl338ii. Thirteen months later some divergent PrPSc phenotypes were seen: a mixture of Apl338ii with either G338 or P338, and a completely novel PrPSc deposition, designated Cag338. The data show that prolonged ageing of scrapie prions within an environmental matrix may result in changes in the dominant PrPSc biological/biochemical properties.
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https://hal.archives-ouvertes.fr/hal-01309780
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Ben C Maddison, John Spiropoulos, Christopher M Vickery, Richard Lockey, Jonathan P Owen, et al.. Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time. Veterinary Research, BioMed Central, 2015, 46 (1), pp.46. ⟨10.1186/s13567-015-0179-y⟩. ⟨hal-01309780⟩

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