T. Carvalho, C. Doerig, and L. Reininger, Nima- and Aurora-related kinases of malaria parasites, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1834, issue.7, pp.1336-1345
DOI : 10.1016/j.bbapap.2013.02.022

S. Yang, A. Sharrocks, and A. Whitmarsh, MAP kinase signalling cascades and transcriptional regulation, Gene, vol.513, issue.1, pp.1-13
DOI : 10.1016/j.gene.2012.10.033

N. Reiner, An exosome-based secretion pathway is responsible for protein export 638 from Leishmania and communication with macrophages, J Cell Sci, vol.123, issue.639, pp.842-852, 2010.

W. Mcmaster, L. Foster, M. Levings, and N. Reiner, Leishmania exosomes 641 modulate innate and adaptive immune responses through effects on monocytes and 642 dendritic cells, J Immunol, vol.185, issue.643, pp.5011-5022, 2011.

U. Knippschild, A. Gocht, S. Wolff, N. Huber, J. Lohler et al., The casein 644 kinase 1 family: participation in multiple cellular processes in eukaryotes, Cell Signal, vol.645, issue.646, pp.675-689, 2005.

B. Nare, Inhibitors of casein kinase 1 block the growth of Leishmania major 648 promastigotes in vitro, Int J Parasitol, vol.36, issue.649, pp.1249-1259, 2006.

J. Silverman, S. Chan, D. Robinson, D. Dwyer, D. Nandan et al., Reiner 650 NE Proteomic analysis of the secretome of Leishmania donovani, Genome Biol, vol.651, issue.20, p.35, 2008.

D. Paape, M. Barrios-llerena, L. Bihan, T. Mackay, L. Aebischer et al., Gel free 653 analysis of the proteome of intracellular Leishmania mexicana, Mol Biochem Parasitol, vol.654, issue.21, pp.108-114, 2010.

J. Reinhardt, Y. Ferandin, and L. Meijer, Purification of CK1 by affinity chromatography on immobilised axin, Protein Expression and Purification, vol.54, issue.1, pp.101-109, 2007.
DOI : 10.1016/j.pep.2007.02.020
URL : https://hal.archives-ouvertes.fr/hal-00169405

Y. Saar, A. Ransford, E. Waldman, S. Mazareb, S. Amin-spector et al., Characterization of developmentally-regulated activities in axenic amastigotes of Leishmania donovani, Molecular and Biochemical Parasitology, vol.95, issue.1, pp.9-20, 1998.
DOI : 10.1016/S0166-6851(98)00062-0

S. Goyard, H. Segawa, J. Gordon, M. Showalter, R. Duncan et al., An in vitro system for developmental and genetic studies of Leishmania donovani 671 phosphoglycans, Mol Biochem Parasitol, vol.670, issue.672, pp.31-42, 2003.

G. Sp?-§th, Phosphoproteomic analysis of Leishmania donovani pro-and 674 amastigote stages, Proteomics, vol.8, issue.675, pp.350-363, 2008.

O. Shimony and C. Jaffe, Rapid fluorescent assay for screening drugs on Leishmania amastigotes, Journal of Microbiological Methods, vol.75, issue.2, pp.196-200, 2008.
DOI : 10.1016/j.mimet.2008.05.026

H. Munier-lehmann, G. Spath, S. Shorte, G. Milon, and E. Prina, High content 679 analysis of primary macrophages hosting proliferating Leishmania amastigotes: 680 application to anti-leishmanial drug discovery, PLoS Negl Trop Dis, vol.7, p.682, 2013.

A. Tarricone, A. Musacchio, S. Roe, L. Pearl, M. Leost et al., Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors, p.688, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00020137

A. Skaltsounis and L. Meijer, 3'-Substituted 7-Halogenoindirubins, a New Class of 696 Cell Death Inducing Agents, Journal of Medicinal Chemistry, vol.49, issue.697, pp.4638-4649, 2006.

T. Schwede, J. Kopp, N. Guex, and M. Peitsch, SWISS-MODEL: an automated protein homology-modeling server, Nucleic Acids Research, vol.31, issue.13, pp.3381-3385, 2003.
DOI : 10.1093/nar/gkg520

L. Schnur, U. Bachrach, G. Bar-ad, M. Haran, Z. Tashma et al., The effect of diaminoalkyl-anthraquinone derivatives on the growth of the 703 promastigotes of Leishmania tropica minor, L. t. major, L. donovani and L. aethiopica, Biochem Pharmacol, vol.702, issue.705, pp.1729-1732, 1983.

M. Bolognesi, F. Lizzi, R. Perozzo, R. Brun, and A. Cavalli, Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity, 2276. 712 38. Conners R, pp.2272-711, 2008.
DOI : 10.1016/j.bmcl.2008.03.009

S. Croft and R. Brady, Mapping the binding site for gossypol-like inhibitors of 714 Plasmodium falciparum lactate dehydrogenase, Mol Biochem Parasitol, vol.142, issue.715, pp.137-148, 2005.

E. Montamat, C. Burgos, G. De-burgos, N. Rovai, L. Blanco et al., Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi, Science, vol.218, issue.4569, pp.288-289, 1982.
DOI : 10.1126/science.6750791

N. Srinivasan and R. Madhubala, Glyoxalase I from Leishmania donovani: a potential 720 target for anti-parasite drug, Biochem Biophys Res Commun, vol.337, issue.721, pp.1237-1248, 2005.

G. Sen, S. Mukhopadhyay, M. Ray, and T. Biswas, Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity, 728 43. da Silva ER, Maquiaveli Cdo C, Magalhaes PP. 2012. The leishmanicidal flavonols 729 quercetin and quercitrin target Leishmania (Leishmania), pp.1066-1075183, 2008.
DOI : 10.1093/jac/dkn053

J. Mottram, M. Soete, J. Dubremetz, L. Roch, K. Doerig et al., Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity 734 chromatography using immobilised inhibitors, Chem Biol, vol.733, issue.735, pp.411-422, 2000.

B. Pollok and P. Connelly, Discovery of a novel, potent, and Src family-selective 737, 1996.

. Tyrosine-kinase-inhibitor, Study of Lck-and FynT-dependent T cell activation, J Biol, vol.738, issue.739, pp.695-701

D. Massillon, W. Stalmans, G. Van-de-werve, and M. Bollen, Identification of the 740 glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor, Biochem J, vol.741, issue.742, pp.299123-128, 1994.

Y. Light, L. Mak, S. Mcglinchey, M. Nowotka, and G. Papadatos, The ChEMBL bioactivity database: an update, Nucleic Acids Res, vol.42, issue.746, pp.1083-745, 2014.

N. Mise, Y. Yokoyama, and H. Yoshida, Src kinase family inhibitor PP2 induces 748 aggregation and detachment of neuroblastoma cells and inhibits cell growth in a PI3 749 kinase/Akt pathway-independent manner, Pediatr Surg Int, vol.27, issue.750, pp.225-230, 2011.

J. Kuret, Crystal structure of a conformation-selective casein kinase-1 inhibitor, p.752, 2000.

R. Fouce, R. Alvarez-velilla, C. Fernandez-prada, C. Garcia-estrada, Y. Kiryu et al., Reguera 754 RM. 2014. Trypanosomatids topoisomerase re-visited. New structural findings and role 755 in drug discovery Anti-cancer activities of 757 pyrazolo[1,5-a]indole derivatives, Biol Chem Int J Parasitol Drugs Drug Resist Chem Pharm Bull, vol.275, issue.758, pp.326-3371628, 2000.

B. Das, A. Ganguly, and H. Majumder, DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy, Adv Exp Med Biol, vol.625, issue.760, pp.103-115, 2008.
DOI : 10.1007/978-0-387-77570-8_9

L. Sanderson, Y. V. Croft, and S. , Activity of anti-cancer protein kinase inhibitors against Leishmania spp., Journal of Antimicrobial Chemotherapy, vol.69, issue.7, pp.1888-1891, 2014.
DOI : 10.1093/jac/dku069

J. Bain, L. Plater, M. Elliott, N. Shpiro, C. Hastie et al., The selectivity of protein kinase inhibitors: a further 764 update Comparative analysis of the 766 kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei 767 and Trypanosoma cruzi, Biochem J BMC Genomics, vol.408, issue.768, pp.297-315127, 2005.

K. Tejle, M. Lindroth, K. Magnusson, and B. Rasmusson, promastigotes block maturation, increase integrin expression and inhibit detachment of human monocyte-derived dendritic cells ?????? the influence of phosphoglycans, Antimicrob 775 Agents Chemother, pp.92-1023033, 2004.
DOI : 10.1111/j.1574-6968.2007.01013.x

A. Skaltsounis and K. Soteriadou, 6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) 778 targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell- 779 cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating 780 leishmaniasis, Int J Parasitol, vol.39, pp.1289-1303, 2009.

A. Skaltsounis, An inhibitor-driven study for enhancing the selectivity of 784 indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial 785 cdc2-related protein kinase 3, Parasit Vectors, vol.7, issue.786, pp.234-60, 2014.

A. Harwood, Signal Transduction in Development, Developmental Cell, vol.2, issue.4, pp.384-385, 2002.
DOI : 10.1016/S1534-5807(02)00156-9

C. Niehrs and J. Shen, Regulation of Lrp6 phosphorylation, Cellular and Molecular Life Sciences, vol.19, issue.15, pp.2551-789, 2010.
DOI : 10.1007/s00018-010-0329-3

V. Bakulev and J. Bischof, The CK1 Family: Contribution to Cellular Stress Response 792 and Its Role in Carcinogenesis, Front Oncol, vol.4, issue.793, pp.96-63, 2014.

E. Beurel, S. Grieco, and R. Jope, Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases, Pharmacology & Therapeutics, vol.148, pp.114-131, 2015.
DOI : 10.1016/j.pharmthera.2014.11.016