Hippocampal microstructural damage and memory impairment in clinically isolated syndrome

Vincent Planche (1) , Aurélie Ruet (2, 3) , Pierrick Coupé (4) , Delphine Lamargue (5) , Mathilde Deloire (3) , Fanny Munsch (1) , Aurore Saubusse (3) , Julie Charré-Morin (3) , Nicolas Moscufo (6) , Dominik Meier (6) , C. R. G. Guttmann (7) , Vincent Dousset (2) , Bruno Brochet (3, 1) , Thomas Tourdias (2)

1 UB - Université de Bordeaux
2 Neuroinflammation: imagerie et thérapie de la sclérose en plaques
3 Service de neurologie [Bordeaux]
4 PICTURA - Patch-based processing for medical and natural images
5 Physiopathologie du système nerveux central - Institut François Magendie
6 Center for Neurological Imaging
7 Center for Neurological Imaging, Department of Radiology

Memory impairment is correlated to hippocampal atrophy in multiple sclerosis (MS) but the substrate of early memory deficit, prior to atrophy, is unknown. We investigated whether early hippocampal alterations are already present at the stage of clinically isolated syndrome suggestive of MS (CIS) and whether they are related to memory performance.

Domaines: Imagerie médicale

Vincent Planche, Aurélie Ruet, Pierrick Coupé, Delphine Lamargue, Mathilde Deloire, et al.. Hippocampal microstructural damage and memory impairment in clinically isolated syndrome. ECTRIMS, Oct 2015, Barcelona, Spain. pp.363. ⟨hal-01294835⟩