Study of Leishmania pathogenesis in mice : experimental considerations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Parasites & Vectors Année : 2016

Study of Leishmania pathogenesis in mice : experimental considerations

Résumé

Although leishmaniases are endemic in 98 countries, they are still considered neglected tropical diseases. Leishmaniases are characterized by the emergence of new virulent and asymptomatic strains of Leishmania spp. and, as a consequence, by a very diverse clinical spectrum. To fight more efficiently these parasites, the mechanisms of host defense and of parasite virulence need to be thoroughly investigated. To this aim, animal models are widely used. However, the results obtained with these models are influenced by several experimental parameters, such as the mouse genetic background, parasite genotype, inoculation route/infection site, parasite dose and phlebotome saliva. In this review, we propose an update on their influence in the two main clinical forms of the disease: cutaneous and visceral leishmaniases.
Fichier principal
Vignette du fichier
document.pdf (550.54 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01942627 , version 1 (03-12-2018)

Identifiants

Citer

Corinne Loeuillet, Anne-Laure Bañuls, Mallorie Hide. Study of Leishmania pathogenesis in mice : experimental considerations. Parasites & Vectors, 2016, 9 (1), ⟨10.1186/s13071-016-1413-9⟩. ⟨hal-01942627⟩
1939 Consultations
97 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More