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Quantitative analysis of metabolic networks and design of minimal bioreaction models

Abstract : This tutorial paper is concerned with the design of macroscopic bioreaction models on the basis a quantitative analysis of the underlying cell metabolism. The paper starts with a review of two fundamental algebraic techniques for the quantitative analysis of metabolic networks : (i) the decomposition of complex metabolic networks into elementary pathways (or elementary modes), (ii) the metabolic flux analysis which aims at computing the entire intracellular flux distribution from a limited number of flux meaurements. Then it is discussed how these two fundamental techniques can be exploited to design minimal bioreaction models by using a systematic model reduction approach that automatically produces a family of equivalent minimal models which are fully compatible with the underlying metabolism and consistent with the available experimental data. The theory is illustrated with an experimental case-study on CHO cells.
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Georges Bastin. Quantitative analysis of metabolic networks and design of minimal bioreaction models. Revue Africaine de la Recherche en Informatique et Mathématiques Appliquées, INRIA, 2008, Volume 9, 2007 Conference in Honor of Claude Lobry, 2008, ⟨10.46298/arima.1891⟩. ⟨hal-01277922⟩



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