S. Fig, Amino-acid alignments of ACR-26 and ACR-27 AChR subunit partial sequences from parasitic nematode species. Parasitic nematode species ACR-26 and ACR-27 partial amino-acid sequences (including the C-loop agonist binding site and the first transmembrane domain (TM1)) were aligned using the MUSCLE algorithm [36] and further processed using GeneDoc. Amino acids conserved between ACR-26 and ACR-27 sequences are highlighted in red. Amino acids specifically shared by ACR-26 homologs are highlighted in dark blue, Amino acids specifically shared by ACR-27 homologs are highlighted in light blue. The ACR-26

. Ovo, Onchocerca volvulus; Wba: Wuchereria bancrofti; Ptr: Parastrongyloides trichosuri; Spa: Strongyloides papillosus; Sra: Strongyloides ratti; Sst: Strongyloides stercoralis; Svz: Strongyloides venezuelensis; Bxy: Bursaphelenchus xylophilus

S. Fig, A and B) Representative recording traces from a single oocyte expressing Hco-L-AChR-1 or Hco-L-AChR-2 challenged with 100 ?M ACh and 100 ?M of different anthelmintic compounds including levamisole (Lev), nicotine (Nic), pyrantel (Pyr) and morantel (Mor) The bars indicate the time period of the agonist application. Functional expression of Hco-L-AChR-1 requires the coexpression of Hco-UNC-38; Hco-UNC-63; Hco-UNC-29, and Hco-ACR-8 AChR subunits with the ancillary proteins Hco-RIC-3.1; Hco-UNC-50 and Hco-UNC-74 whereas Hco- L-AChR-2 requires the co-expression of Hco-UNC-38; Hco-UNC-63 and Hco-UNC-29

S. Fig, ACR-27 from H. contortus or P. equorum in C. elegans increases its sensitivity to pyrantel (50 ?M) but does not modulate its sensitivity to levamisole (5 ?M) Thrashing assays were performed during 30 minutes with t0 corresponding to basal movements. For each C. elegans co-expressing ACR-26 and ACR-27 from H. contortus (A and B) or P. equorum (C and D), two independent lines were used with >12 worms per lines, Thrashing assays performed with 50 ?M Pyr or 5 ?M Lev on N2 (WT) and transformed worms co-expressing ACR-26 and ACR-27 subunits. All results are expressed as mean ± SEM

S. Table, Summary of Hco-acr-26 and Hco-acr-27 homologs identified in genomic databases from nematodes Nematode clades as determined by Life style abbreviations: VP: vertebrate parasite; IP: Insect parasite; FL: free-living.; WBP: Worm BaseParasite. Database abbreviations: SI: Sanger Institute (www.sanger.ac.uk); NN: Nematode Net V4, WBP: WormBase Parasitewormbase.org/). Ã complete or partial cDNA sequence available. (DOCX)

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