Synthesis, resolution, and determination of absolute configuration of protected α- [alpha]-ethynylphenylalanine enantiomers

Abstract : Racemic-protected α-ethynylphenylalanine was synthesized from dl-2-benzylserine using α-benzylserinal as key intermediate and was uccessfully resolved by HPLC on a chiral stationary phase at a semipreparative scale. The absolute configuration of both enantiomers was determined by vibrational circular dichroism.
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https://hal.archives-ouvertes.fr/hal-01274000
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Submitted on : Monday, February 15, 2016 - 10:56:23 AM
Last modification on : Tuesday, May 28, 2019 - 5:04:07 PM

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Zohra Benfodda, David Bénimélis, Marion Jean, Jean-Valère Naubron, Valérie Rolland, et al.. Synthesis, resolution, and determination of absolute configuration of protected α- [alpha]-ethynylphenylalanine enantiomers. Amino Acids, Springer Verlag, 2015, ⟨10.10007/s00726-015-1917-1⟩. ⟨hal-01274000⟩

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