Impact of early complications on outcomes in patients with implantable cardioverter-defibrillator for primary prevention

Abstract : Background The lifesaving benefit of implantable cardioverter-defibrillators (ICDs) has been demonstrated. Their use has increased considerably in the past decade, but related complications have become a major concern. Objective The purpose of this study was to assess the incidence and effect on outcomes of early (≤30 days) complications after ICD implantation for primary prevention in a large French population. Methods We analyzed data from 5539 patients from the multicenter French DAI-PP (Défibrillateur Automatique Implantable–Prévention Primaire) registry (2002−2012) who had coronary artery disease or dilated cardiomyopathy and were implanted with an ICD for primary prevention. Results Overall, early complications occurred in 707 patients (13.5%), mainly related to lead dislodgment or hematoma (57%). Independent factors associated with occurrence of early complications were severe renal impairment (odds ratio [OR] 1.66, 95% confidence interval [CI] 1.17–2.37, P = .02), age ≥75 years (OR 1.01, 95% CI 1.00–1.02, P = .03), cardiac resynchronization therapy (OR 1.58, 95% CI 1.16-2.17, P = .01), and anticoagulant therapy (OR 1.28, 95% CI 1.02-1.61, P = .03). During a mean ± SD follow-up of 3.1 ± 2.3 years, 824 (15.8%) patients experienced ≥1 late complication (>30 days), and 782 (14.9%) patients died. After adjustment, early complications remained associated with occurrence of late complications (OR 2.15, 95% CI 1.73-2.66, P < .0001) and mortality (OR 1.70, 95% CI 1.34-2.17, P = .003).
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Maria Soledad Ascoeta, Eloi Marijon, Pascal Defaye, Didier Klug, Frankie Beganton, et al.. Impact of early complications on outcomes in patients with implantable cardioverter-defibrillator for primary prevention. Heart Rhythm, Elsevier, 2016, In press. ⟨10.1016/j.hrthm.2015.12.046⟩. ⟨hal-01272165⟩

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