Neonatal Mortality and Long-Term Outcome of Infants Born between 27 and 32 Weeks of Gestational Age in Breech Presentation: The EPIPAGE Cohort Study

Elie Azria (1, 2) , Gilles Kayem (3, 1, 2, 4) , Bruno Langer (5) , Laetitia Marchand-Martin (1) , Stephane Marret (6, 7) , Jeanne Fresson (8, 9, 10, 11) , Véronique Pierrat (5, 12, 1, 2, 10) , Catherine Arnaud (13) , François Goffinet (5, 12, 14, 1, 2, 4, 10, 13) , Monique Kaminski (1) , Pierre-Yves Ancel (1)

1 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
2 Service d'Obstétrique
3 UPMC - Université Pierre et Marie Curie - Paris 6
4 CHU Trousseau [APHP]
5 Service de gynécologie–obstétrique
6 Service de Pédiatrie Néonatale et Réanimation – Neuropédiatrie [CHU Rouen]
7 Néovasc - Endothélium microcirculatoire cérébral et lésions du système nerveux central au cours du développement
8 Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé
9 Service d'Epidémiologie
10 Rouen Institute for Biomedical Research
11 Medical Information Department [Nancy]
12 Service de Médecine Néonatale
13 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
14 Service de Gynécologie et Obstétrique [Cochin]

Objective To determine whether breech presentation is an independent risk factor for neonatal morbidity, mortality, or long-term neurologic morbidity in very preterm infants. Design Prospective population-based cohort. Population Singletons infants without congenital malformations born from 27 to 32 completed weeks of gestation enrolled in France in 1997 in the EPIPAGE cohort. Methods The neonatal and long-term follow-up outcomes of preterm infants were compared between those in breech presentation and those in vertex presentation. The relation of fetal presentation with neonatal mortality and neurodevelopmental outcomes was assessed using multiple logistic regression models. Results Among the 1518 infants alive at onset of labor included in this analysis (351 in breech presentation), 1392 were alive at discharge. Among those eligible to follow up and alive at 8 years, follow-up data were available for 1188 children. Neonatal mortality was significantly higher among breech than vertex infants (10.8% vs. 7.5%, P = 0.05). However the differences were not significant after controlling for potential confounders. Neonatal morbidity did not differ significantly according to fetal presentation. Severe cerebral palsy was less frequent in the group born in breech compared to vertex presentation but there was no difference after adjustment. There was no difference according to fetal presentation in cognitive deficiencies/learning disabilities or overall deficiencies. Conclusion Our data suggest that breech presentation is not an independent risk factor for neonatal mortality or long-term neurologic deficiencies among very preterm infants.

Domaines: Santé publique et épidémiologie

Elie Azria, Gilles Kayem, Bruno Langer, Laetitia Marchand-Martin, Stephane Marret, et al.. Neonatal Mortality and Long-Term Outcome of Infants Born between 27 and 32 Weeks of Gestational Age in Breech Presentation: The EPIPAGE Cohort Study. PLoS ONE, 2016, 11 (1), pp.e0145768. ⟨10.1371/journal.pone.0145768.t005⟩. ⟨hal-01270729⟩