Use of liver volatile compounds as markers of animal exposure to toxic contaminants

Jihene Bouhlel (1, 2) , Jérémy Ratel (2) , Saïd Abou El Karam (2) , Elisabeth Baéza (3) , Catherine Jondreville (4) , Douglas Rutledge (1) , Erwan Engel (2)

1 GENIAL - Ingénierie, Procédés, Aliments
2 QuaPA - Qualité des Produits Animaux
3 URA - Unité de Recherches Avicoles
4 URAFPA - Unité de Recherches Animal et Fonctionnalités des Produits Animaux

Nowadays, the control of the contamination of the food chain by toxic xenobiotics became a major safety issue given the strong relationships pointed out between chronic exposure to contaminants and pathologies such as cancers. This issue is particularly critical for animal-derived food products. The current methods operated to ensure this control are expensive, difficult to set up and unsuitable with frequent, regular and large-scale controls required to guarantee effectively the chemical safety of food. A new approach to trace-back these toxic xenobiotics along the food chain may consist in measuring markers of animal exposure to contaminants through omics approach. Among the various classes of metabolism end-products, we focused on volatile compounds which were identified as promising biomarkers to detect pathologies [11] or exposure to contaminants [10]. The present study aims to set up a SPME-MS fingerprinting method to point out the relevance of volatile metabolites in hepatic tissues as markers of chicken exposure to three types of xenobiotics: (i) an organochlorinated insecticide _lindane (γ-HCH), (ii) an environmental micropollutants_a mix of polychlorobiphenyls (PCBs), and (iii) an antibiotic _ ampicillin (Ampisol).

Mots clés: food safety; toxic contaminant; volatile biomarkers

Domaines: Alimentation et Nutrition

Jihene Bouhlel, Jérémy Ratel, Saïd Abou El Karam, Elisabeth Baéza, Catherine Jondreville, et al.. Use of liver volatile compounds as markers of animal exposure to toxic contaminants. 61. International Congress of Meat Science and Technology (ICoMST), Aug 2015, Clermont-Ferrand, France. ⟨hal-01269282⟩