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Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas.

Abstract : In the neocortex, higher-order areas are essential to integrate sensory-motor information and have expanded in size during evolution. How higher-order areas are specified, however, remains largely unknown. Here, we show that the migration and distribution of early-born neurons, the Cajal-Retzius cells (CRs), controls the size of higher-order areas in the mouse somatosensory, auditory, and visual cortex. Using live imaging, genetics, and in silico modeling, we show that subtype-specific differences in the onset, speed, and directionality of CR migration determine their differential invasion of the developing cortical surface. CR migration speed is cell autonomously modulated by vesicle-associated membrane protein 3 (VAMP3), a classically non-neuronal mediator of endosomal recycling. Increasing CR migration speed alters their distribution in the developing cerebral cortex and leads to an expansion of postnatal higher-order areas and congruent rewiring of thalamo-cortical input. Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring.
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https://hal.archives-ouvertes.fr/hal-01266802
Contributor : Martine Bondidier <>
Submitted on : Wednesday, February 3, 2016 - 1:55:01 PM
Last modification on : Tuesday, January 5, 2021 - 4:42:01 PM

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Melissa Barber, Yoko Arai, Yoshihiro Morishita, Lisa Vigier, Frédéric Causeret, et al.. Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas.. Current Biology - CB, Elsevier, 2015, 25 (19), pp.2466-78. ⟨10.1016/j.cub.2015.08.028⟩. ⟨hal-01266802⟩

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