J. Bain, H. Mclauchlan, M. Elliott, and P. Cohen, The specificities of protein kinase inhibitors: an update, Biochem. J, vol.371, pp.199-204, 2003.

N. P. Belichenko, P. V. Belichenko, A. M. Kleschevnikov, A. Salehi, R. H. Reeves et al., The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome, Journal of Neuroscience, vol.29, issue.18, pp.5938-5948, 2009.
DOI : 10.1523/JNEUROSCI.1547-09.2009

J. Braudeau, B. Delatour, A. Duchon, P. L. Pereira, L. Dauphinot et al., Specific targeting of the GABA-A receptor ??5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice, Journal of Psychopharmacology, vol.25, issue.8, pp.1030-1042, 2011.
DOI : 10.1177/0269881111405366
URL : https://hal.archives-ouvertes.fr/hal-00634143

A. R. Carta, A. Pinna, O. Cauli, and M. Morelli, Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittentL-dopa and A2A receptor blockade plusL-Dopa in dopamine-denervated rats, Synapse, vol.12, issue.3, pp.166-174, 2002.
DOI : 10.1002/syn.10066

M. T. Davisson, C. Schmidt, R. H. Reeves, N. G. Irving, E. C. Akeson et al., Segmental trisomy as a mouse model for Down syndrome, Prog. Clin. Biol. Res, vol.384, pp.117-133, 1993.

J. M. Delabar, D. Theophile, Z. Rahmani, Z. Chettouh, J. L. Blouin et al., Molecular mapping of twenty-four features of Down syndrome on chromosome 21, Eur. J. Hum. Genet, vol.1, pp.114-124, 1993.

R. De-la-torre, S. De-sola, M. Pons, A. Duchon, M. M. De-lagran et al., Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans, Molecular Nutrition & Food Research, vol.7, issue.2, pp.278-288, 2014.
DOI : 10.1002/mnfr.201300325

W. K. Dowjat, T. Adayev, I. Kuchna, K. Nowicki, S. Palminiello et al., Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome, Neuroscience Letters, vol.413, issue.1, pp.77-81, 2007.
DOI : 10.1016/j.neulet.2006.11.026

M. Faizi, P. L. Bader, C. Tun, A. Encarnacion, A. Kleschevnikov et al., Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of ??1-adrenergic receptor by xamoterol as a potential cognitive enhancer, Neurobiology of Disease, vol.43, issue.2, pp.397-413, 2011.
DOI : 10.1016/j.nbd.2011.04.011

F. Fernandez, W. Morishita, E. Zuniga, J. Nguyen, M. Blank et al., Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome, Nat. Neurosci, vol.10, pp.411-413, 1860.

S. Granon, C. Vidal, C. Thinus-blanc, J. P. Changeux, and B. Poucet, Working memory, response selection, and effortful processing in rats with medial prefrontal lesions., Behavioral Neuroscience, vol.108, issue.5, pp.883-891, 1994.
DOI : 10.1037/0735-7044.108.5.883
URL : https://hal.archives-ouvertes.fr/hal-01385332

F. Guedj, P. L. Pereira, S. Najas, M. J. Barallobre, C. Chabert et al., DYRK1A: A master regulatory protein controlling brain growth, Neurobiology of Disease, vol.46, issue.1, pp.190-203, 2012.
DOI : 10.1016/j.nbd.2012.01.007

F. Guedj, C. Sébrié, I. Rivals, A. Ledru, E. Paly et al., Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A, PLoS ONE, vol.21, issue.25, 2009.
DOI : 10.1371/journal.pone.0004606.s001

M. A. Haas, D. Bell, A. Slender, E. Lana-elola, S. Watson-scales et al., Alterations to Dendritic Spine Morphology, but Not Dendrite Patterning, of Cortical Projection Neurons in Tc1 and Ts1Rhr Mouse Models of Down Syndrome, PLoS ONE, vol.106, issue.10, 2013.
DOI : 10.1371/journal.pone.0078561.g005

S. Himpel, P. Panzer, K. Eirmbter, H. Czajkowska, M. Sayed et al., Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A, Biochemical Journal, vol.359, issue.3, pp.497-505, 1042.
DOI : 10.1042/bj3590497

A. M. Kleschevnikov, P. V. Belichenko, M. Faizi, L. F. Jacobs, K. Htun et al., Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists, Journal of Neuroscience, vol.32, issue.27, pp.9217-9227, 2012.
DOI : 10.1523/JNEUROSCI.1673-12.2012

S. Lanfranchi, E. Toffanin, S. Zilli, B. Panzeri, and R. Vianello, Memory coding in individuals with Down syndrome, Child Neuropsychology, vol.36, issue.6, pp.700-712, 2014.
DOI : 10.1111/j.1365-2788.2004.00478.x

C. Martínez-cué, P. Martínez, N. Rueda, R. Vidal, S. Garcia et al., Reducing GABAA ??5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome, Journal of Neuroscience, vol.33, issue.9, pp.3953-3966, 2013.
DOI : 10.1523/JNEUROSCI.1203-12.2013

Y. Ogawa, Y. Nonaka, T. Goto, E. Ohnishi, T. Hiramatsu et al., Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A, Nature Communications, vol.27, issue.7, pp.86-96, 1038.
DOI : 10.1038/ncomms1090

L. G. Reinholdt, Y. Ding, G. J. Gilbert, A. Czechanski, J. P. Solzak et al., Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn, Mammalian Genome, vol.19, issue.11-12, pp.685-691, 2011.
DOI : 10.1007/s00335-011-9357-z

A. Ronan, K. Fagan, L. Christie, J. Conroy, N. J. Nowak et al., Familial 4.3 Mb duplication of 21q22 sheds new light on the Down syndrome critical region, Journal of Medical Genetics, vol.44, issue.7, pp.448-451047373, 2006.
DOI : 10.1136/jmg.2006.047373

B. Souchet, F. Guedj, I. Sahún, A. Duchon, F. Daubigney et al., Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage, Neurobiology of Disease, vol.69, pp.65-75, 2014.
DOI : 10.1016/j.nbd.2014.04.016

F. Tejedor, X. R. Zhu, E. Kaltenbach, A. Ackermann, A. Baumann et al., minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila, Neuron, vol.14, issue.2, pp.287-301, 1995.
DOI : 10.1016/0896-6273(95)90286-4

A. Thomazeau, O. Lassalle, J. Iafrati, B. Souchet, F. Guedj et al., Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a, Journal of Neuroscience, vol.34, issue.4, pp.1138-1147, 2014.
DOI : 10.1523/JNEUROSCI.2852-13.2014

A. Tlili, F. Jacobs, L. D. De-koning, S. Mohamed, L. C. Bui et al., Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1832, issue.6, pp.718-728, 2013.
DOI : 10.1016/j.bbadis.2013.02.008

B. W. Van-bon, A. Hoischen, J. Hehir-kwa, A. P. De-brouwer, C. Ruivenkamp et al., Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly, Clinical Genetics, vol.17, issue.4, pp.296-299, 2011.
DOI : 10.1111/j.1399-0004.2010.01544.x