Completing signaling networks by abductive reasoning with perturbation experiments

Abstract : We propose in this paper an abductive method that allows, given a biological network, to check whether some experimental observations can be causally explained by the network and to use the unexplained observations to complete the network. We then apply the method on the FSHR-induced signaling network.
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Contributor : Adrien Rougny <>
Submitted on : Wednesday, January 20, 2016 - 10:23:42 AM
Last modification on : Thursday, March 21, 2019 - 2:14:26 PM

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  • HAL Id : hal-01259205, version 1

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Adrien Rougny, Yoshitaka Yamamoto, Hidetomo Nabeshima, Gauvain Bourgne, Anne Poupon, et al.. Completing signaling networks by abductive reasoning with perturbation experiments. 25th International Conference on Inductive Logic Programming, Aug 2015, Kyoto, Japan. 〈hal-01259205〉

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