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Completing signaling networks by abductive reasoning with perturbation experiments
Adrien Rougny
1
Yoshitaka Yamamoto
2
Hidetomo Nabeshima
2
Gauvain Bourgne
3
Anne Poupon
4
Katsumi Inoue
5
Christine Froidevaux
1
Adrien Rougny 1
Author
Yoshitaka Yamamoto 2
Author
Hidetomo Nabeshima 2
Author
Gauvain Bourgne 3
Author IdHAL : gauvain-bourgne
Anne Poupon 4
Author Employer institution : Centre National de la Recherche Scientifique IdHAL : anne-poupon ORCID : https://orcid.org/0000-0003-0617-0935
Katsumi Inoue 5
Author
Christine Froidevaux 1
Author IdHAL : christine-froidevaux
1
LRI - Laboratoire de Recherche en Informatique (LRI - Bâtiments 650-660 Université Paris-Sud 91405 Orsay Cedex - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- CentraleSupélec (3, rue Joliot Curie, Plateau de Moulon, 91192 GIF-SUR-YVETTE Cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR8623 (France)
2
Yamanashi University (Kofu Campus 4-4-37, Takeda, Kofu, Yamanashi, 400-8510 Japan - Japan)
3
ACASA - Agents Cognitifs et Apprentissage Symbolique Automatique (France)
- LIP6 - Laboratoire d'Informatique de Paris 6 (4 Place JUSSIEU 75252 PARIS CEDEX 05 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7606 (France)
4
PRC - Physiologie de la reproduction et des comportements [Nouzilly] (Centre de Recherches de Tours 37380 Nouzilly - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 7247/ UMR6175 / UMR 6073 (France)
- UT - Université de Tours (60 rue du Plat d'Étain, 37020 Tours cedex 1 - France)
- IFCE - Institut Français du Cheval et de l'Equitation [Saumur] (Terrefort, BP 207, F-49411 Saumur - France)
- INRA - Institut National de la Recherche Agronomique : UR0085 (France)
5
NII - National Institute of Informatics (2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo 101-8430 - Japan)
Abstract : We propose in this paper an abductive method that allows, given a biological network, to check whether some experimental observations can be causally explained by the network and to use the unexplained observations to complete the network. We then apply the method on the FSHR-induced signaling network.
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Conference papers
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https://hal.archives-ouvertes.fr/hal-01259205
Contributor : Adrien Rougny Connect in order to contact the contributor
Submitted on : Wednesday, January 20, 2016 - 10:23:42 AM
Last modification on : Friday, May 6, 2022 - 2:22:08 PM
Contributor : Adrien Rougny Connect in order to contact the contributor
Submitted on : Wednesday, January 20, 2016 - 10:23:42 AM
Last modification on : Friday, May 6, 2022 - 2:22:08 PM
Identifiers
- HAL Id : hal-01259205, version 1
Collections
CNRS | INRA | UPMC | UMR8623 | LIP6 | LRI-BIOINFO | UNIV-PARIS-SACLAY | CENTRALESUPELEC | UNIV-TOURS | SORBONNE-UNIVERSITE | SU-SCIENCES | INRAE | GS-COMPUTER-SCIENCE | PHASE
Citation
Adrien Rougny, Yoshitaka Yamamoto, Hidetomo Nabeshima, Gauvain Bourgne, Anne Poupon, et al.. Completing signaling networks by abductive reasoning with perturbation experiments. 25th International Conference on Inductive Logic Programming, Aug 2015, Kyoto, Japan. ⟨hal-01259205⟩
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